Mesoporous silica with precisely controlled pores reduces food efficiency and suppresses weight gain in mice
| Autor: | Maria Lindgren, Mia Rinde, Eric V. Johnston, Natalia Kupferschmidt, Ghislaine Robert-Nicoud, Tore Bengtsson, Muhammad Iqbal |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Biomedical Engineering Medicine (miscellaneous) Adipose tissue Bioengineering 02 engineering and technology Development Diet High-Fat Weight Gain 03 medical and health sciences Mice Internal medicine Diabetes mellitus medicine Animals Humans General Materials Science Obesity 030304 developmental biology Adiposity 0303 health sciences Chemistry Leptin Metabolism Mesoporous silica 021001 nanoscience & nanotechnology medicine.disease Silicon Dioxide Mice Inbred C57BL Disease Models Animal Endocrinology Mechanism of action Adipose Tissue Nanoparticles medicine.symptom 0210 nano-technology Weight gain |
| Zdroj: | Nanomedicine (London, England). 15(2) |
| ISSN: | 1748-6963 |
| Popis: | Aim: Obesity is a risk factor for cardiovascular disease and diabetes. We aimed to elucidate the effects of distinct mesoporous silica particles (MSPs) supplemented in food on metabolic parameters in obesity. Materials & methods: MSPs with precisely controlled pore size were synthesized, characterized and compared with a control in a C57Bl/6 mouse diet-induced obesity model, studying weight, adiposity, metabolic regulation and food efficiency. Results: The most effective MSPs reduced adipose tissue formation to 6.5 ± 0.5 g compared with 9.4 ± 1.2 g, leptin levels nearly halved from 32.8 ± 7.4 to 16.9 ± 1.9 ng/ml and a 33% reduction of food efficiency. Control MSP showed no effects. Conclusion: Results demonstrate potential of distinct MSPs to improve metabolic risk factors. Further studies investigating mechanism of action and confirming human safety are needed. |
| Databáze: | OpenAIRE |
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