Neonatal jaundice with reference to aflatoxins: an aetiological study in Zaria, northern Nigeria
| Autor: | R. G. Hendrickse, S. M. Maxwell, H. Ahmed, A. M. Yakubu |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Pediatrics
medicine.medical_specialty Aflatoxin Cord 030231 tropical medicine Population Physiology Nigeria Umbilical cord Severity of Illness Index 03 medical and health sciences 0302 clinical medicine Aflatoxins Pregnancy 030225 pediatrics medicine Humans heterocyclic compounds Prospective Studies Prospective cohort study education education.field_of_study business.industry Incidence technology industry and agriculture Infant Newborn food and beverages Jaundice Fetal Blood biological factors Jaundice Neonatal medicine.anatomical_structure Cord blood Case-Control Studies Prenatal Exposure Delayed Effects Pediatrics Perinatology and Child Health Etiology Female medicine.symptom business |
| Zdroj: | Annals of tropical paediatrics. 15(1) |
| ISSN: | 0272-4936 |
| Popis: | Two prospective studies were undertaken to determine a possible relationship between perinatal aflatoxin exposure and neonatal jaundice. First, cord blood samples from 37 neonates who subsequently developed jaundice and from 40 non-jaundiced (control) babies were analysed for six major aflatoxins and aflatoxicol. Peripheral blood samples of both groups were also analysed postnatally for aflatoxins. In a second study, serum aflatoxin levels of 64 jaundiced neonates admitted from outside the hospital were compared with levels in 60 non-jaundiced control babies. Aflatoxins were detected in 14 (37.8%) cord blood samples of jaundiced neonates and in nine (22.5%) of the controls. The mean cord aflatoxin concentration was highest in jaundiced neonates with septicaemia, but the difference was not statistically significant. The frequency of detection of aflatoxins in peripheral blood was not significantly different in jaundiced and non-jaundiced babies. Aflatoxins were detected in the blood of over 50% of neonates with jaundice of 'unknown' aetiology. There was no correlation between severity of hyperbilirubinaemia and serum aflatoxin levels. Further studies are needed to determine the extent of pre- and postnatal exposure to aflatoxin in Nigerian infants and the effects of such exposure on fetal and neonatal health. |
| Databáze: | OpenAIRE |
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