The activity of commercial antimicrobials, and essential oils and ethanolic extracts of Olea europaea on Streptococcus agalactiae isolated from pregnant women
| Autor: | Benson Chucks Iweriebor, Larry Chikwelu Obi, Anthony I. Okoh, Sylvester R. Moyo, Munyaradzi Mukesi, Uchechukwu U. Nwodo |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Cefotaxime
Erythromycin Microbial Sensitivity Tests medicine.disease_cause Microbiology Streptococcus agalactiae 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Anti-Infective Agents Levofloxacin Pregnancy Ampicillin Olea Streptococcal Infections medicine Oils Volatile Humans Pregnancy Complications Infectious Olea europaea business.industry Plant Extracts Clindamycin General Medicine lcsh:Other systems of medicine biochemical phenomena metabolism and nutrition bacterial infections and mycoses lcsh:RZ201-999 β Lactams 030205 complementary & alternative medicine Complementary and alternative medicine chemistry 030220 oncology & carcinogenesis Linezolid Ceftriaxone Female Antimicrobial business medicine.drug Research Article |
| Zdroj: | BMC Complementary and Alternative Medicine, Vol 19, Iss 1, Pp 1-9 (2019) BMC Complementary and Alternative Medicine |
| ISSN: | 1472-6882 |
| Popis: | Background Streptococcus agalactiae also known as Group B Streptococcus (GBS) is a major cause of disease in pregnant women and new born babies where it causes early and late onset disease characterised by sepsis, pneumonia and meningitis. Ten to 37 % of pregnant women in the world are colonised with GBS while intrapartum antibiotic prophylaxis has led to significant reduction in early onset disease. The increase in drug resistant microorganisms has become a major threat. Development of vaccines is still in progress so there is need for new and safer alternatives to treatment. Methods Benzyl penicillin, Ampicillin, Cefotaxime, Ceftriaxone, Levofloxacin, Erythromycin, Clindamycin, Linezolid, Vancomycin, Tetracycline and Cotrimoxazole, Olea europaea leaf extracts and essential oil were tested against GBS isolates from South Africa and Namibia. Results The isolates showed 100% sensitivity to benzyl penicillin, ampicillin, ceftriaxone, levofloxacin, linezolid, vancomycin, O. europaea leaf extracts and essential oils. Only one isolate (0.6%) was resistant to cefotaxime and 23.4 and 10.4% were resistant to clindamycin and erythromycin respectively. Conclusion GBS isolates showed sensitivity to O. europaea extracts at low minimum inhibitory concentrations. Β lactams are still the drugs of choice for treatment of GBS disease but O. europaea extracts potent as an alternative source of antimicrobials. |
| Databáze: | OpenAIRE |
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