Transcholesterin Titers and Their Biological Significance in Experimental Atherogenesis in Rats
| Autor: | Beverly Jean Neff, Todor Krasteff, Gerald L. Brody, Thomas Francis, Nan-Sing Ling |
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| Rok vydání: | 1968 |
| Předmět: |
Male
medicine.medical_specialty Arachis Arteriosclerosis Blood lipids Immunoelectrophoresis Biology General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Blood serum Internal medicine Alpha-Globulins medicine Animals Homeostasis Alpha globulin medicine.diagnostic_test Cholesterol Dietary Fats Rats Titer Endocrinology chemistry Blood chemistry Spectrophotometry Immunology Butter Diet Atherogenic Oils Protein Binding |
| Zdroj: | Experimental Biology and Medicine. 128:300-307 |
| ISSN: | 1535-3699 1535-3702 |
| Popis: | SummaryThe rise in titer of transcholesterin in the sera of rats on different high-fat or atherogenic diets was demonstrated. The reactive component is a serum alpha globulin which appears to combine specifically with cholesterol in agar gel immunoelectrophoresis. The serum cholesterol levels rise in various degrees in relation to diets but they do not correlate directly with transcholesterin titers. The observations suggest that transcholesterin functions as a homeostatic mechanism to meet the excess demands in disposal of cholesterol. The prompt rise of serum transcholesterin titer in rats on the high-fat diets and the moderate hypercholesterolemia may represent the adequacy of transcholesterin function in these animals. On an atherogenic diet, extreme heights of serum total cholesterol are reached early, again with mobilization of transcholesterin, after which the latter declines suggesting the homeostatic effort is approaching exhaustion or that the transcholesterin has been so fully combined that lit... |
| Databáze: | OpenAIRE |
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