Once weekly azithromycin in secondary prevention of rheumatic fever
| Autor: | Jagan Mohan Tharakan, S. Sivasankaran, V.K. Ajithkumar, Sivadasanpillai Harikrishnan, Thomas Titus, Rakesh Gopal |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male lcsh:Diseases of the circulatory (Cardiovascular) system medicine.medical_specialty Time Factors Heart disease medicine.drug_class Antibiotics lcsh:Surgery Administration Oral India Azithromycin medicine.disease_cause Drug Administration Schedule Throat culture Young Adult Recurrence Streptococcal Infections Internal medicine Secondary Prevention medicine Sore throat Humans Rheumatic fever Developing Countries medicine.diagnostic_test Prophylaxis Streptococcus business.industry Pharyngitis lcsh:RD1-811 Penicillin medicine.disease Anti-Bacterial Agents Surgery stomatognathic diseases Treatment Outcome lcsh:RC666-701 Penicillin V Female Original Article medicine.symptom Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Indian Heart Journal, Vol 64, Iss 1, Pp 12-15 (2012) |
| ISSN: | 0019-4832 |
| Popis: | Rheumatic fever and rheumatic heart disease (RHD) are still important problems in developing countries. Secondary prophylaxis which is the most cost-effective method in preventing recurrences of rheumatic fever is fraught with problems of drug compliance. The utility of 500 mg once weekly azithromycin (AZT), an orally effective long-acting antibiotic was evaluated against oral penicillin (phenoxy methyl penicillin 250 mg twice daily) in this study. Forty-eight consecutive patients (44% males, mean age 29.4 years) with established RHD were randomised into two groups-26 patients received AZT and 22 received oral penicillin. Patients were evaluated at randomisation, at 1 month, 3 months, and 6 months, clinically, serologically and by throat swab culture. End points were absence of streptococcal colonisation, infection or fever at the end of 6 months. During the study, 4 patients (15.4%) in the AZT group developed sore throat and fever, had positive throat culture and positive serology indicating streptococcal infection. None satisfied the criteria for rheumatic fever reactivation. None in the oral penicillin group developed streptococcal infection. In conclusion, weekly 500 mg of AZT is not effective in the prevention of streptococcal throat infection compared to oral penicillin therapy in adult patients with established RHD. |
| Databáze: | OpenAIRE |
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