Population Dynamics and Genetic Diversity of C4 Strains of Human Enterovirus 71 in Mainland China, 1998–2010

Autor: Leng Liu, Dawei Guan, Hanri Zeng, Marion Koopmans, Juan Su, Xue Guo, Cong Ma, Changwen Ke, Sabine van der Sanden, Xin Zhang, Huanying Zheng, Wei Li, Zheng Liu
Přispěvatelé: Virology
Rok vydání: 2012
Předmět:
Viral Diseases
Epidemiology
lcsh:Medicine
Population genetics
Disease Outbreaks
Clinical Epidemiology
lcsh:Science
Phylogeny
education.field_of_study
Multidisciplinary
Foot-and-mouth disease
Infectious Diseases
Medical Microbiology
Genetic Epidemiology
Medicine
Monte Carlo Method
Algorithms
Research Article
Mainland China
China
Clinical Research Design
Molecular Sequence Data
Population
Zoology
Biology
Microbiology
Viral Evolution
Infectious Disease Epidemiology
SDG 3 - Good Health and Well-being
stomatognathic system
Virology
medicine
Humans
Amino Acid Sequence
Typing
education
Genetic diversity
Sequence Homology
Amino Acid
Population Biology
lcsh:R
Genetic Variation
Outbreak
Bayes Theorem
Sequence Analysis
DNA
medicine.disease
Enterovirus A
Human
Enterovirus Infection
DNA
Viral
Mutation
lcsh:Q
Hand
Foot and Mouth Disease
Zdroj: PLoS ONE, Vol 7, Iss 9, p e44386 (2012)
PLoS ONE, 7(9):e44386. Public Library of Science
PLoS ONE
ISSN: 1932-6203
Popis: Background: Since 1997, several countries within the Asian Pacific region have been affected by one or more massive outbreaks of Hand Foot and Mouth Disease (HFMD). Virus typing experiments revealed that these outbreaks were caused by strains of human enterovirus 71 (EV71) belonging to several different, recently emerged subgenogroups. In mainland China, a different situation was observed. The first outbreak, localized in Shangdong Province, was reported in 2007, and was followed by a wide-spread outbreak in mainland China in 2008. Since then, numbers of reported HFMD cases have been persistently high. Methodology/Principal Findings: To gain insight in the epidemiological behavior of EV71 in China, we studied genetic diversity and EV71 population dynamics to address whether the increase in number of reported EV71 infections reflects a real increase in viral spread or is just the result of increased awareness and surveillance. We used systematically collected VP1 gene sequences of 257 EV71 strains collected in Guangdong province from 2008 to 2010 as part of HFMD surveillance activities, and supplemented them with 305 GenBank EV71 reference stains collected in China from 1998 to 2010. All isolates from Guangdong Province belonged to subgenogroup C4. Viral population dynamics indicated that the increased reporting of HFMD in China since 2007 reflects a real increase in viral spread and continued replacement of viral lineages through time. Amino acid sequence comparisons revealed substitution of amino acid in residues 22, 145 and 289 through time regularly with the VP1 gene of EV71 strains isolated in mainland China from 1998 to 2010. Conclusions: EV71 strains isolated in mainland China mainly belonged to subgenogroup C4. There was exponential growth of the EV71 virus population in 2007 and 2008. There was amino acid substitution through time regularly with the VP1 gene which possibly increased viral spread and/or ability of the virus to circulate persistently among the Chinese population.
Databáze: OpenAIRE
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