Zinc, Vitamin A, and Micronutrient Supplementation in Children with Diarrhea: A Randomized Controlled Clinical Trial of Combination Therapy versus Monotherapy
| Autor: | Utpala Mitra, Krishnan Rajendran, Dutta P, Mrinal Kanti Chatterjee, Trailokya Nath Naik, Shanta Dutta |
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| Rok vydání: | 2011 |
| Předmět: |
Diarrhea
Male Vitamin medicine.medical_specialty chemistry.chemical_element Zinc Placebo Gastroenterology law.invention Feces chemistry.chemical_compound Double-Blind Method Randomized controlled trial law Internal medicine Humans Medicine Micronutrients Vitamin B12 Vitamin A Dehydration business.industry Infant Micronutrient Surgery Clinical trial chemistry Acute Disease Dietary Supplements Pediatrics Perinatology and Child Health Fluid Therapy Drug Therapy Combination medicine.symptom business |
| Zdroj: | The Journal of Pediatrics. 159:633-637 |
| ISSN: | 0022-3476 |
| DOI: | 10.1016/j.jpeds.2011.03.028 |
| Popis: | To compare the clinical efficacy of supplementation of zinc, zinc plus vitamin A, and zinc plus combination of micronutrients and vitamins (iron, copper, selenium, vitamin B(12), folate, and vitamin A) on acute diarrhea in children.This was a double-blind, randomized, placebo-controlled trial. Children aged 6 to 24 months with diarrhea and moderate dehydration were randomized to receive zinc plus placebo vitamin A (group 1), zinc plus other micronutrients plus vitamin A (group 2), zinc plus vitamin A (group 3), or placebo (group 4) as an adjunct to oral rehydration solution. Duration, volume of diarrhea, and consumption of oral rehydration solution were compared as outcome variables within the supplemented groups and with the placebo group.The 167 study subjects included 41 in group 1, 39 in group 2, 44 in group 3, and 43 in group 4. All 3 supplemented groups demonstrated a significant reduction in outcome variables (P.0001) compared with the placebo group. Group 3 had the lowest reduction of outcome variables and group 2 had a speedy recovery, but differences among the supplemented groups were not statistically significant.Supplementation with a combination of micronutrients and vitamins was not superior to zinc alone, confirming the clinical benefit of zinc in children with diarrhea. |
| Databáze: | OpenAIRE |
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