Mortality From Respiratory Syncytial Virus in Children Under 2 Years of Age: A Prospective Community Cohort Study in Rural Maharashtra, India
| Autor: | Phyllis Carosone-Link, Vibhawari Dani, Varsha Potdar, Eric A. F. Simões, Danielle Hessong, Mandeep S. Chadha, Shilpa Satav, Sameer Palaskar, Rowena Crow, Ashish Satav |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Microbiology (medical)
medicine.medical_specialty Pediatrics medicine.medical_treatment India Supplement Articles Respiratory Syncytial Virus Infections Cohort Studies Lower respiratory tract infection Case fatality rate Epidemiology medicine Humans Prospective Studies Respiratory tract infections business.industry Mortality rate Infant medicine.disease Infant mortality infant mortality Infectious Diseases AcademicSubjects/MED00290 Respiratory Syncytial Virus Human acute lower respiratory infection (ALRI) epidemiology business Watchful waiting Cohort study |
| Zdroj: | Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America |
| ISSN: | 1537-6591 |
| Popis: | Background Although respiratory syncytial virus (RSV) is the most important viral cause of lower respiratory tract infection deaths in infants, there are few data on infant community deaths caused by RSV. Methods This was an active surveillance of children younger than 2 years of age in 93 villages, 5 primary health centers, and 3 hospitals serving these villages. Village health workers and counselors at the health facilities monitored all lower respiratory tract infections (LRTIs) in consented subjects. Children with severe, or very severe LRTIs and all who died, had nasopharyngeal swabs collected for detection of RSV by molecular methods. Results In the 12 134 subjects, there were 2064 episodes of severe LRTIs and 1732 of very severe LRTIs, of which 271 and 195, respectively, had RSV. Fifteen of 16 (94%) children with RSV died of LRTIs, 14 in the community and 1 in the hospital. The case fatality ratios for severe RSV LRTIs in the first 6 months of life were 3/52 (7.1%) and 1/36 (2.8%) in the community and hospital, respectively. Of those with very severe LRTIs in the community, 17.6% died. There were no very severe RSV LRTI hospital deaths. The adjusted RSV LRTI mortality rates ranged from 1.0 to 3.0/1000 child-years (CY) overall, and 2.0 to 6.1/1000 CY, accounting for 20% of the LRTI deaths and 10% of the postneonatal infant mortality. Conclusions Community deaths from RSV account for the majority of RSV LRTI deaths, and efforts at prevention should be preferentially directed at populations where access to care is limited. Respiratory syncytial virus is the most important viral cause of lower respiratory tract infection deaths in infants, and efforts at prevention should be preferentially directed at populations where access to care is limited. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|