Inflammatory profile dysregulation in nuclear workers occupationally exposed to low-dose gamma radiation

Autor: Elena Zaharieva, Gergana Savova, Olya Katsarska, Nevena Aneva, Rayna Boteva, Katia Stankova, Jana Djounova
Rok vydání: 2019
Předmět:
Adult
Male
inflammatory cytokines
Health
Toxicology and Mutagenesis
medicine.medical_treatment
Population
chronic radiation exposure
Physiology
Inflammation
low-dose radiation
Antioxidants
Proinflammatory cytokine
03 medical and health sciences
0302 clinical medicine
nuclear workers
Occupational Exposure
Blood plasma
Regular Paper
medicine
Humans
Radiology
Nuclear Medicine and imaging
education
030304 developmental biology
0303 health sciences
education.field_of_study
Radiation
business.industry
Monocyte
Chronic radiation syndrome
biomarkers
Dose-Response Relationship
Radiation
Middle Aged
Radiation Exposure
Cytokine
medicine.anatomical_structure
Gamma Rays
030220 oncology & carcinogenesis
Case-Control Studies
Nuclear Power Plants
NOD-like receptor protein 4
Hypertension
Linear Models
Cytokines
Tumor necrosis factor alpha
medicine.symptom
Erratum
business
Zdroj: Journal of Radiation Research
ISSN: 1349-9157
Popis: Chronic inflammation is a common denominator linking a wide range of health conditions, including tissue response to radiation exposure. This pilot study investigates whether inflammatory cytokines—interleukins IL-6, −8, −10, monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor α (TNFα)—can be used as early biomarkers of radiation-induced adverse health effects in occupationally exposed individuals. The study included 33 workers externally exposed to gamma radiation from the nuclear industry with cumulated doses from 0.11 to 190 mSv and 42 non-exposed controls of comparable age and socio-economic status. IL-6, IL-8, MCP-1, TNFα and IL-10 were analyzed by enzyme-linked assay (ELISA) in blood plasma samples. Total antioxidant status (TAS) of blood plasma was determined by a colorimetric assay. The radiation-exposed and control groups measured significantly different levels of MCP-1, TNFα and IL-10. Seventy-five percent of radiation workers had either high MCP-1 levels or low IL-10 levels and 30% had all three cytokines dysregulated. Approximately 50% of workers showed upregulated antioxidant status, which appeared to compensate the pro-inflammatory cytokine shift in these individuals. In contrast, only 2% of the control subjects were found to have three dysregulated cytokines, and all of them measured within the normal TAS range. The present study may represent an important step towards the establishment of a reliable set of biomarkers for health-risk estimation in population cohorts exposed to low radiation doses.
Databáze: OpenAIRE
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