Patients’ perceptions of the negative effects following different prostate cancer treatments and the impact on psychological well-being: a nationwide survey

Autor: Heli Tenhola, Arpo Aromaa, Ulla-Sisko Lehto, Kimmo Taari
Přispěvatelé: Clinicum, Department of Surgery, Urologian yksikkö, HUS Abdominal Center
Rok vydání: 2017
Předmět:
Male
Oncology
Cancer Research
patient satisfaction
population study: prostate cancer
medicine.medical_treatment
Brachytherapy
Prostate cancer
0302 clinical medicine
Antineoplastic Combined Chemotherapy Protocols
030212 general & internal medicine
Aged
80 and over
Cervical cancer
education.field_of_study
Prostatectomy
Middle Aged
Prognosis
Combined Modality Therapy
3142 Public health care science
environmental and occupational health
3. Good health
side effects
030220 oncology & carcinogenesis
medicine.medical_specialty
urologia
Urology
education
Population
03 medical and health sciences
Patient satisfaction
Breast cancer
Internal medicine
medicine
Humans
Watchful Waiting
Aged
Neoplasm Staging
business.industry
Prostatic Neoplasms
3126 Surgery
anesthesiology
intensive care
radiology
medicine.disease
patient reported outcome
Urinary Incontinence
quality of life
Clinical Study
psychological well-being
Perception
Skin cancer
business
Follow-Up Studies
Zdroj: British Journal of Cancer
ISSN: 1532-1827
0007-0920
DOI: 10.1038/bjc.2017.30
Popis: Background: Although the prognosis of localised prostate cancer is good, the negative effects of prostate cancer treatment often impair patient quality of life. A growing number of men experience these negative effects over a longer time because of the increased incidence of and prolonged survival in prostate cancer, and the ageing of the population. Only a few studies have investigated the adverse effects of different prostate cancer treatments using large population-based samples. Methods: We conducted a nationwide survey (n=1239) to collect detailed information regarding the negative effects (i.e., the occurrence, perceived level and perceived bother since the beginning of the treatment) of prostate cancer treatments: radical prostatectomy, external beam radiotherapy, brachytherapy, hormone therapy and surveillance. Furthermore, we measured patient satisfaction with the outcome of the treatment and their psychological well-being (i.e., psychological symptoms and satisfaction with life) 5 years after diagnosis. The negative effects between the treatments were compared, and the determinants of satisfaction and psychological well-being were investigated. Results: The negative effects of all types of active prostate cancer treatments were common and persistent (33–48% reported symptoms at 5 years) and showed the known differences between the treatments. Prostatectomy and the radiotherapies caused urinary leakage; radiotherapy also caused symptoms of urinary irritation; and external radiation also caused bowel dysfunction. Most symptoms were considered highly bothersome. Most respondents (81−93%) reported that their treatment negatively affected their sex lives; 70–92% reported sexual dysfunction; and 20–58% reported that their sex lives with their spouses had ended. Urinary symptoms were especially associated with poorer psychological outcomes. The perception of symptom level and bother had a greater effect on patient satisfaction and well-being than the symptoms per se. Conclusion: Multiple and persistent negative effects follow active prostate cancer treatment, and these effects predict long-term patient satisfaction and psychological well-being. The harms and benefits associated with prostate cancer treatments should be considered when selecting whether and how to actively treat prostate cancer.
Databáze: OpenAIRE
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