Estimating Glomerular Filtration Rate in Older People
| Autor: | Alberto Montesanto, Sergio Fusco, Vincenzo Mari, Andrea Corsonello, Marcello Maggio, Sabrina Garasto, Antonio Marino, Francesco De Rango, Fabrizia Lattanzio, Maria Rosignuolo, Francesco Corica |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Aging medicine.medical_specialty Adverse outcomes lcsh:Medicine Early detection Renal function Review Article General Biochemistry Genetics and Molecular Biology Older population chemistry.chemical_compound Serum cystatin Internal medicine medicine Humans Vulnerable population Intensive care medicine outcome assessment Aged Aged 80 and over Creatinine geriatrics chronic kidney disease comorbidity General Immunology and Microbiology business.industry lcsh:R General Medicine Endocrinology chemistry Female Older people business Glomerular Filtration Rate |
| Zdroj: | BioMed Research International BioMed Research International, Vol 2014 (2014) |
| ISSN: | 2314-6141 2314-6133 |
| Popis: | We aimed at reviewing age-related changes in kidney structure and function, methods for estimating kidney function, and impact of reduced kidney function on geriatric outcomes, as well as the reliability and applicability of equations for estimating glomerular filtration rate (eGFR) in older patients. CKD is associated with different comorbidities and adverse outcomes such as disability and premature death in older populations. Creatinine clearance and other methods for estimating kidney function are not easy to apply in older subjects. Thus, an accurate and reliable method for calculating eGFR would be highly desirable for early detection and management of CKD in this vulnerable population. Equations based on serum creatinine, age, race, and gender have been widely used. However, these equations have their own limitations, and no equation seems better than the other ones in older people. New equations specifically developed for use in older populations, especially those based on serum cystatin C, hold promises. However, further studies are needed to definitely accept them as the reference method to estimate kidney function in older patients in the clinical setting. |
| Databáze: | OpenAIRE |
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