Seizures Induced by Desloratadine, A Second-Generation Antihistamine: Clinical Observations
| Autor: | Adriana Lo Castro, Denis Roberto, Nadia El-Malhany, Paolo Curatolo, Caterina Cerminara |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Histamine H1 Antagonists Non-Sedating Adolescent medicine.medical_treatment Pharmacology chemistry.chemical_compound Epilepsy Hypersensitivity medicine Humans Child Desloratadine business.industry Histaminergic General Medicine Loratadine medicine.disease Histamine H1 Antagonists Seizure susceptibility chemistry Child Preschool Anesthesia Pediatrics Perinatology and Child Health Female Antihistamine Neurology (clinical) business Histamine medicine.drug |
| Zdroj: | Neuropediatrics. 44:222-224 |
| ISSN: | 1439-1899 0174-304X |
| DOI: | 10.1055/s-0033-1333871 |
| Popis: | Some clinical experiences indicate that H1-antihistamines, especially first-generation H1-antagonists, occasionally provoke convulsions in healthy children as well as epileptic patients. Desloratadine is a frequently used second-generation antihistamine considered to be effective and safe for the treatment of allergic diseases. We describe four children who experienced epilepsy associated with the nonsedating H(1)-antagonist desloratadine and discuss the neurophysiologic role of the central histaminergic system in seizure susceptibility. In conclusion, we recommend caution in treating epileptic patients with the histamine H(1)-antagonists, including second- and third-generation drugs that are frequently referred because they are considered to be nonsedating antihistamines. |
| Databáze: | OpenAIRE |
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