Management of Eosinophilic Esophagitis Based on Pathophysiological Evidence
| Autor: | Bram D. van Rhijn, Albert J. Bredenoord |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Epithelial barrier medicine.medical_specialty business.industry Gastroenterology Severe disease Treatment options Proton Pump Inhibitors Eosinophilic Esophagitis Treatment goals medicine.disease Pathophysiology Disease activity 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Internal medicine medicine Humans 030211 gastroenterology & hepatology Dietary therapy Eosinophilic esophagitis Intensive care medicine business |
| Zdroj: | Journal of clinical gastroenterology. 51(8):659-668 |
| ISSN: | 0192-0790 |
| DOI: | 10.1097/mcg.0000000000000879 |
| Popis: | Over the past decades eosinophilic esophagitis (EoE) has been increasingly diagnosed, and significant progress has been made in our understanding of its pathophysiology. As EoE cannot be cured yet, treatment goals are suppression of disease activity and symptoms as well as the prevention of progression to a more severe disease phenotype. Disease-modifying treatment options can be divided into dietary therapy and immunosuppressive medications, of which topical steroids have been most investigated, yet are still prescribed off-label. In this review, we will summarize recent advances in our understanding of EoE and discuss the mechanisms of action of current treatment options, with emphasis on the role of the esophageal epithelial barrier and the effects of proton-pump inhibitors in the management of patients with EoE. |
| Databáze: | OpenAIRE |
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