Reproducibility of Striatal and Thalamic Dopamine D2 Receptor Binding Using [11C]raclopride with High-Resolution Positron Emission Tomography
| Autor: | Terhi Tuokkola, Jarkko Johansson, Matti Laine, Sargo Aalto, Juha O. Rinne, K. Någren, Kati Alakurtti, Vesa Oikonen |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Caudate nucleus Young Adult Thalamus Dopamine receptor D2 Image Processing Computer-Assisted medicine Humans Raclopride Reproducibility medicine.diagnostic_test Receptors Dopamine D2 Chemistry business.industry Putamen Dopamine antagonist Reproducibility of Results Binding potential Signal Processing Computer-Assisted Corpus Striatum Neurology Positron emission tomography Area Under Curve Isotope Labeling Positron-Emission Tomography Dopamine Antagonists Original Article Neurology (clinical) Radiopharmaceuticals Cardiology and Cardiovascular Medicine Nuclear medicine business Algorithms medicine.drug |
| Zdroj: | Journal of Cerebral Blood Flow & Metabolism. 31:155-165 |
| ISSN: | 1559-7016 0271-678X |
| Popis: | Positron emission tomography (PET) imaging of small striatal brain structures such as the ventral striatum (VST) has been hampered by low spatial resolution causing partial-volume effects. The high-resolution research tomograph (HRRT) is a brain-dedicated PET scanner that has considerably better spatial resolution than its predecessors. However, its superior spatial resolution is associated with a lower signal-to-noise ratio. We evaluated the test–retest reliability of the striatal and thalamic dopamine D2 receptor binding using the HRRT scanner. Seven healthy male volunteers underwent two [11C]raclopride PET scans with a 2.5-hour interval. Dopamine D2 receptor availability was quantified as binding potential (BPND) using the simplified reference tissue model. To evaluate the reproducibility of repeated BPND estimations, absolute variability (VAR) and intraclass correlation coefficients (ICCs) were calculated. VAR values indicated fairly good reproducibility and were 3.6% to 4.5% for the caudate nucleus and putamen and 4.5% to 6.4% for the lateral and medial part of the thalamus. In the VST, the VAR value was 5.8% when the definition was made in the coronal plane. However, the ICC values were only moderate, in the range of 0.34 to 0.66, for all regions except the putamen (0.87). Experimental signal processing methods improved neither ICC nor VAR values significantly. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|