Obesity and subcutaneous fat patterning in relation to survival of postmenopausal breast cancer patients participating in the DOM-project
| Autor: | Jacob C. Seidell, de Waard F, Fracheboud J, den Tonkelaar I |
|---|---|
| Přispěvatelé: | Youth and Lifestyle |
| Rok vydání: | 1995 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty Population Breast Neoplasms Research Support Breast cancer screening Breast cancer SDG 3 - Good Health and Well-being Internal medicine Receptors Journal Article Humans Mass Screening Medicine Comparative Study Obesity Prospective Studies Non-U.S. Gov't education Prospective cohort study Estrogen Receptor Status Survival analysis Mass screening Aged Neoplasm Staging education.field_of_study medicine.diagnostic_test business.industry Research Support Non-U.S. Gov't Middle Aged Prognosis medicine.disease Estrogen Survival Analysis Postmenopause Endocrinology Receptors Estrogen Adipose Tissue Body Composition Female Lymph Nodes business Follow-Up Studies |
| Zdroj: | Breast Cancer Research and Treatment, 34(2), 129-37. Springer New York den Tonkelaar, I, de Waard van de Spek, FB, Seidell, J C & Fracheboud, J 1995, ' Obesity and subcutaneous fat patterning in relation to survival of postmenopausal breast cancer patients participating in the DOM-project ', Breast Cancer Research and Treatment, vol. 34, no. 2, pp. 129-37 . https://doi.org/10.1007/BF00665785 |
| ISSN: | 1573-7217 0167-6806 |
| DOI: | 10.1007/bf00665785 |
| Popis: | The effect of obesity and fat distribution on survival of breast cancer patients was studied prospectively in 241 women with a natural menopause who participated in a breast cancer screening project, the DOM-project in Utrecht, The Netherlands. Mean follow-up time was 9.1 years and endpoint of interest was death from breast cancer. Fat distribution was assessed by contrasting groups of subscapular and triceps skinfold thickness. No significant differences in survival time between more obese (Quetelet's index > or = 26 kg/m2) and leaner (Quetelet's index < 26 kg/m2) patients or between patients with central fat distribution and patients with peripheral fat distribution were observed. Analyses were stratified by axillary node status, estrogen receptor status, and way of detection (by first screening or afterwards). Results of the stratified analyses were suggestive of a modifying effect of these factors. The absence of an association between obesity and survival time might be explained by two counteracting mechanisms. On the one hand obesity might be related to impaired survival, due to a tumor growth promoting effect of extra-ovarian estrogens. On the other hand obesity might be related to improved survival in a screened population, because obese patients profit more from screening by earlier detection of tumors than leaner counterparts. |
| Databáze: | OpenAIRE |
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