Sequential cleavage and blastocyst embryo transfer and IVF outcomes: a systematic review
| Autor: | Chong Wang, Jianeng Zhang, Yan Zhou, Huanhuan Zhang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
QH471-489
Pregnancy Rate medicine.medical_treatment Cleavage Stage Ovum Fertilization in Vitro Cochrane Library Cleavage (embryo) Andrology Endocrinology Cleavage embryo transfer Pregnancy In vitro fertilization medicine Humans Sequential embryo transfer Blastocyst In vitro fertilisation business.industry Reproduction Research Blastocyst Transfer Pregnancy Outcome Obstetrics and Gynecology Embryo Gynecology and obstetrics Embryo Transfer Embryo Mammalian Embryo transfer Study heterogeneity medicine.anatomical_structure Treatment Outcome Reproductive Medicine Infertility embryonic structures RG1-991 Systematic review Female business Developmental Biology Blastocyst embryo transfer |
| Zdroj: | Reproductive Biology and Endocrinology : RB&E Reproductive Biology and Endocrinology, Vol 19, Iss 1, Pp 1-9 (2021) |
| ISSN: | 1477-7827 2021-8001 |
| Popis: | BackgroundSequential embryo transfer has been proposed as a way to improve embryo implantation in women forin vitrofertilization (IVF), but the effect on pregnancy outcomes remains ambiguous. This systematic review was conducted to investigate the efficacy of sequential embryo transfer on IVF outcomes.MethodsA literature search was performed in the PubMed, Web of Science, Cochrane Library, ScienceDirect and Wanfang databases. Data were pooled using a random- or fixed-effects model according to study heterogeneity. The results are expressed as relative risks (RRs) with 95% confidence intervals (CIs). Heterogeneity was evaluated by the I2statistic. The study protocol was registered prospectively on INPLASY, ID: INPLASY202180019.ResultsTen eligible studies with 2658 participants compared sequential embryo transfer and cleavage transfer, while four studies with 513 participants compared sequential embryo transfer and blastocyst transfer. The synthesis results showed that the clinical pregnancy rate was higher in the sequential embryo transfer group than in the cleavage embryo transfer group (RR 1.42, 95% CI 1.26–1.60,P< 0.01) for both women who did experience repeated implantation failure (RIF) (RR 1.58, 95% CI 1.17–2.13,P< 0.01) and did not experience RIF (Non-RIF) (RR 1.44, 95% CI 1.20–1.66,P< 0.01). However, sequential embryo transfer showed no significant benefit over blastocyst embryo transfer.ConclusionThe current systematic review demonstrates that sequential cleavage and blastocyst embryo transfer improve the clinical pregnancy rate over conventional cleavage embryo transfer. For women with adequate embryos, sequential transfer could be attempted following careful consideration. More high-grade evidence from prospective randomized studies is warranted. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink