Amygdala Functional Connectivity Features in Grief: A Pilot Longitudinal Study
| Autor: | Shi-Jiang Li, Joseph S. Goveas, Gang Chen, Stacy A. Claesges, B. Douglas Ward |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Longitudinal study medicine.medical_specialty media_common.quotation_subject Pilot Projects Audiology Amygdala Article 03 medical and health sciences 0302 clinical medicine Neural Pathways medicine Humans Longitudinal Studies Default mode network Aged media_common Brain Mapping 030214 geriatrics medicine.diagnostic_test business.industry Magnetic resonance imaging medicine.disease Magnetic Resonance Imaging humanities Complicated grief Psychiatry and Mental health medicine.anatomical_structure Case-Control Studies Anxiety Female Grief Geriatrics and Gerontology medicine.symptom Functional magnetic resonance imaging business |
| Zdroj: | Am J Geriatr Psychiatry |
| ISSN: | 1064-7481 |
| DOI: | 10.1016/j.jagp.2020.02.014 |
| Popis: | Objective Acute grief, in an important minority of older adults, can become protracted, intense, and debilitating, leading to the development of complicated grief (CG). However, the neurobiologic mechanisms underlying a maladaptive grief response after an attachment loss are unknown. The current study aimed to examine the amygdala brain network features that cross-sectionally explain the symptom variance and longitudinally relate to grief symptom trajectories after an attachment loss. Methods Baseline amygdala functional connectivity (Fc) was assessed using a seed-based resting-state functional magnetic resonance imaging method in 35 adults who were within 1-year after death of a loved one and 21 healthy comparison (HC) participants. Magnetic resonance imaging scans were obtained at baseline, and clinical assessments, including the inventory of complicated grief (ICG) were completed at weeks 0, 8, 16, and 26 (endpoint). Results Relative to HC participants, grief participants showed increased amygdala Fc in the posterior default mode (bilateral medial temporal lobes and left precuneus) and thalamus. Amygdala Fc in the default mode and ventral affective regions positively correlated with ICG scores at baseline. Furthermore, increased baseline amygdala functional connections with the dorsal frontal executive control and salience network regions correlated with worsening ICG scores over time. These longitudinal findings persisted after controlling for covariates, including baseline depressive and anxiety symptoms. Conclusion These results provide novel preliminary evidence suggesting amygdala-based brain network measures to cross-sectionally explain symptom variance and longitudinally correlate with grief symptom trajectories in grievers. Amygdala brain network function measures may have the potential to serve as biomarkers of CG. |
| Databáze: | OpenAIRE |
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