Organ-on-a-chip: the next generation platform for risk assessment of radiobiology
| Autor: | Albert van den Berg, Yanbo Xie, Yi Quan, Jan C.T. Eijkel, Zhaoyi Tan, Andries D. van der Meer, Miao Sun |
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| Rok vydání: | 2020 |
| Předmět: |
0303 health sciences
Radiobiology Computer science General Chemical Engineering media_common.quotation_subject General Chemistry Organ-on-a-chip Regenerative medicine 03 medical and health sciences 0302 clinical medicine Risk analysis (engineering) Application domain 030220 oncology & carcinogenesis Risk assessment Function (engineering) 030304 developmental biology media_common |
| Zdroj: | RSC Advances. 10:39521-39530 |
| ISSN: | 2046-2069 |
| DOI: | 10.1039/d0ra05173j |
| Popis: | Organ-on-a-chip devices have been widely used in biomedical science and technology, for example for experimental regenerative medicine and precision healthcare. The main advantage of organ-on-a-chip technology is the facility to build a specific human model that has functional responses on the level of organs or tissues, thereby avoiding the use of animal models, as well as greatly improving new drug discovery processes for personal healthcare. An emerging application domain for organs-on-chips is the study of internal irradiation for humans, which faces the challenges of the lack of a clear model for risk estimation of internal irradiation. We believe that radiobiology studies will benefit from organ-on-a-chip technology by building specific human organ/tissues in vitro. In this paper, we briefly reviewed the state-of-the-art in organ-on-a-chip research in different domains, and conclude with the challenges of radiobiology studies at internal low-dose irradiation. Organ-on-a-chip technology has the potential to significantly improve the radiobiology study as it can mimic the function of human organs or tissues, and here we summarize its potential benefits and possible breakthrough areas, as well as its limitations in internal low-dose radiation studies. This journal is |
| Databáze: | OpenAIRE |
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