Asymptomatic intracranial aneurysms in beta-thalassemia: a three-year follow-up report
| Autor: | Sara Ponticorvo, Silverio Perrotta, Antonietta Canna, Martina Caiazza, Camilla Russo, Angela Ciancio, Maddalena Casale, Rosanna Di Concilio, Renzo Manara, Fabrizio Esposito, Domenico Roberti, Immacolata Tartaglione, Andrea Elefante, Caterina Maietta, Andrea G. Russo, Daniela Capalbo, Mario Cirillo, Elisa De Michele |
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| Přispěvatelé: | Manara, R., Caiazza, M., Di Concilio, R., Ciancio, A., De Michele, E., Maietta, C., Capalbo, D., Russo, C., Roberti, D., Casale, M., Elefante, A., Esposito, F., Ponticorvo, S., Russo, A. G., Canna, A., Cirillo, M., Perrotta, S., Tartaglione, I. |
| Rok vydání: | 2020 |
| Předmět: |
Adult
medicine.medical_specialty Subarachnoid hemorrhage lcsh:Medicine 030204 cardiovascular system & hematology Aneurysm Beta-thalassemia Magnetic resonance angiography Asymptomatic 03 medical and health sciences 0302 clinical medicine medicine Humans Pharmacology (medical) cardiovascular diseases Prospective Studies Genetics (clinical) medicine.diagnostic_test business.industry Research lcsh:R beta-Thalassemia Beta thalassemia Intracranial Aneurysm General Medicine Middle Aged medicine.disease Cerebral Angiography Surgery Natural history medicine.anatomical_structure Transfusion dependence Female medicine.symptom business 030217 neurology & neurosurgery Follow-Up Studies Artery |
| Zdroj: | Orphanet Journal of Rare Diseases Orphanet Journal of Rare Diseases, Vol 15, Iss 1, Pp 1-4 (2020) |
| ISSN: | 1750-1172 |
| DOI: | 10.1186/s13023-020-1302-3 |
| Popis: | Background No information is currently available regarding the natural history of asymptomatic intracranial aneurysms in beta-thalassemia, raising several concerns about their proper management. Methods We performed a prospective longitudinal three-year-long MR-angiography study on nine beta-thalassemia patients (mean-age 40.3 ± 7.5, six females, 8 transfusion dependent) harboring ten asymptomatic intracranial aneurysms. In addition, we analyzed the clinical files of all adult beta-thalassemia patients (160 patients including those followed with MR-angiography, 121 transfusion dependent) referring to our Centers between 2014 and 2019 searching for history of subarachnoid hemorrhage or history of symptomatic intracranial aneurysms. Results At the end of the three-year-long follow-up, no patient showed any change in the size and shape of the aneurysms, none presented new intracranial aneurysms or artery stenoses, none showed new brain vascular-like parenchymal lesions or enlargement of the preexisting ones. Besides, in our database of all adult beta-thalassemia patients, no one had history of subarachnoid hemorrhage or history of symptomatic intracranial aneurysms. Conclusions Incidental asymptomatic intracranial aneurysms do not seem to be associated, in beta-thalassemia, with an increased risk of complications (enlargement or rupture) at least in the short term period, helping to optimize human and economic resources and patient compliance during their complex long-lasting management. |
| Databáze: | OpenAIRE |
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