Determination of fumonisin B1 levels in body fluids and hair from piglets fed fumonisin B1-contaminated diets
| Autor: | Pollyana Cristina Maggio de Castro Souto, Fernando Gustavo Tonin, George E. Rottinghaus, Mayra Carraro Di Gregorio, Isabelle P. Oswald, Tânia Petta, Anne-Marie Cossalter, Carlos Augusto Fernandes de Oliveira, Philippe Pinton, Alessandra Vincenzi Jager |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Fumonisin B1 Chromatography TOXICOLOGIA DE ALIMENTOS 010401 analytical chemistry General Medicine Urine Contamination Toxicology 01 natural sciences 0104 chemical sciences 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology chemistry Fumonisin Toxicokinetics Food science Feces Food Science |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| Popis: | The levels of fumonisin B1 (FB1) residues in plasma, urine, feces and hair from 24 piglets fed FB1-contaminated diets containing 3.1, 6.1 or 9.0 μg FB1.g−1 for 28 days were determined using liquid chromatography coupled to mass spectrometry (LC-MS/MS). The levels of FB1 in plasma, urine, feces and pooled hair (n = 3) samples varied from 0.15 to 1.08 μg.L−1, 16.09–75.01 μg.L−1, 1.87–13.89 μg.g−1 and 2.08–8.09 ng.g−1, respectively. Significant correlations (r = 0.808–0.885; P 14 days). The possibility to evaluate hair as a biomarker of fumonisin exposure was established, although further studies are needed to provide physiologically based toxicokinetics of residual FB1 in the pig hair. |
| Databáze: | OpenAIRE |
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