Reduced activation in the ventral striatum during probabilistic decision-making in patients in an at-risk mental state
| Autor: | Daniela Mier, Mathias Zink, Sabrina Fenske, Frederike Schirmbeck, Claudia Schilling, Sarah Eifler, Susanne Englisch, Peter Kirsch, Andreas Meyer-Lindenberg, Franziska Rausch |
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| Přispěvatelé: | Adult Psychiatry |
| Rok vydání: | 2015 |
| Předmět: |
Male
Risk medicine.medical_specialty Decision Making Prodromal Symptoms Neuropsychological Tests medicine.disease_cause Lorazepam Brain mapping behavioral disciplines and activities Young Adult Jumping ddc:150 mental disorders Schizophrenic Psychology medicine Humans Hypnotics and Sedatives Pharmacology (medical) Young adult Psychiatry Biological Psychiatry Probability Brain Mapping Ventral striatum At risk mental state medicine.disease Magnetic Resonance Imaging Antidepressive Agents Ventral tegmental area Psychiatry and Mental health medicine.anatomical_structure Cross-Sectional Studies nervous system Schizophrenia Ventral Striatum Female Psychology Neuroscience Research Paper |
| Zdroj: | Journal of psychiatry & neuroscience, 40(3), 163-173. Canadian Medical Association |
| ISSN: | 1488-2434 1180-4882 |
| Popis: | Background: Patients with schizophrenia display metacognitive impairments, such as hasty decision-making during probabilistic reasoning - the "jumping to conclusion" bias (JTC). Our recent fMRI study revealed reduced activations in the right ventral striatum (VS) and the ventral tegmental area (VTA) to be associated with decision-making in patients with schizophrenia. It is unclear whether these functional alterations occur in the at-risk mental state (ARMS).Methods: We administered the classical beads task and fMRI among ARMS patients and healthy controls matched for age, sex, education and premorbid verbal intelligence. None of the ARMS patients was treated with antipsychotics. Both tasks request probabilistic decisions after a variable amount of stimuli. We evaluated activation during decision-making under certainty versus uncertainty and the process of final decision-making.Results: We included 24 AMRS patients and 24 controls in our study. Compared with controls, ARMS patients tended to draw fewer beads and showed significantly more JTC bias in the classical beads task, mirroring findings in patients with schizophrenia. During fMRI, ARMS patients did not demonstrate JTC bias on the behavioural level, but showed a significant hypoactivation in the right VS during the decision stage.Limitations: Owing to the cross-sectional design of the study, results are constrained to a better insight into the neurobiology of risk constellations, but not prepsychotic stages. Nine of the ARMS patients were treated with antidepressants and/or lorazepam.Conclusion: As in patients with schizophrenia, a striatal hypoactivation was found in ARMS patients. Confounding effects of antipsychotic medication can be excluded. Our findings indicate that error prediction signalling and reward anticipation may be linked to striatal dysfunction during prodromal stages and should be examined for their utility in predicting transition risk. published |
| Databáze: | OpenAIRE |
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