Proprotein convertases: Key players in inflammation-related malignancies and metastasis
| Autor: | Geraldine Siegfried, Abdel-Majid Khatib, Serge Evrard, Jean Descarpentrie |
|---|---|
| Přispěvatelé: | Laboratoire Angiogenèse et Micro-environnement des Cancers (LAMC), Université Sciences et Technologies - Bordeaux 1-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Bergonié [Bordeaux], UNICANCER, CCSD, Accord Elsevier |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Cancer Research Chemokine Carcinogenesis [SDV]Life Sciences [q-bio] Inflammation Article Metastasis 03 medical and health sciences 0302 clinical medicine Neoplasms medicine Tumor Microenvironment Animals Humans Enzyme Inhibitors Neoplasm Metastasis Antineoplastic Agents Alkylating Tumor microenvironment biology Substrates business.industry Protein maturation medicine.disease Extravasation 3. Good health [SDV] Life Sciences [q-bio] Disease Models Animal 030104 developmental biology Oncology α1-PDX Tumor progression 030220 oncology & carcinogenesis Cancer cell biology.protein Cancer research Disease Progression Selectins Proprotein Convertases medicine.symptom Chemokines business Signal Transduction |
| Zdroj: | Cancer Letters Cancer Letters, Elsevier, 2020, 473, pp.50-61. ⟨10.1016/j.canlet.2019.12.027⟩ Cancer Letters, 2020, 473, pp.50-61. ⟨10.1016/j.canlet.2019.12.027⟩ |
| ISSN: | 0304-3835 |
| DOI: | 10.1016/j.canlet.2019.12.027⟩ |
| Popis: | Many cancers occur from locations of inflammation due to chronic irritation and/or infection. Tumor microenvironment contains various different inflammatory cells and mediators that orchestrate diverse neoplastic processes, including proliferation, survival, adhesion and migration. In parallel, tumor cells have adapted some of the signaling molecules used by inflammatory cells, such as selectins and chemokines as well as their receptors for invasion, extravasation and subsequently metastasis. Expression and/or activation of the majority of these molecules is mediated by the proprotein convertases (PCs); proteases expressed by both tumor cells and inflammatory cells. This review analyzes the potential role of these enzymatic system in inflammation-associated cancer impacting on the malignant and metastatic potential of cancer cells, describing the possible use of PCs as a new anti-inflammatory therapeutic approach to tumor progression and metastasis. Highlights • Proteins maturation by the proprotein convertases plays important role in inflammation-related cancer and metastasis. • Protein precursors require the proprotein convertases for the induction of inflammation. • Understanding of the molecular mechanism linking the proprotein convertases to inflammation will allow novel therapies. • Inhibitors of the proprotein convertases constitute great potential for cancer treatment. |
| Databáze: | OpenAIRE |
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