Distribution of Fluvoxamine and Identification of the Main Metabolite in a Fatal Intoxication
| Autor: | Matteo Moretti, Luca Tajana, Luca Morini, Antonio Marco Maria Osculati, Jessica Quaiotti, Claudia Vignali, Francesca Freni |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Gabapentin Health Toxicology and Mutagenesis Metabolite Serotonin reuptake inhibitor Fluvoxamine Propranolol Toxicology 01 natural sciences Gastroenterology Gas Chromatography-Mass Spectrometry Analytical Chemistry 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine Haloperidol Bile Humans Environmental Chemistry 030216 legal & forensic medicine Adverse effect Clotiapine Chemical Health and Safety business.industry 010401 analytical chemistry Middle Aged 0104 chemical sciences chemistry Female business Selective Serotonin Reuptake Inhibitors Chromatography Liquid medicine.drug |
| Zdroj: | Journal of Analytical Toxicology. 45:e1-e5 |
| ISSN: | 1945-2403 0146-4760 |
| DOI: | 10.1093/jat/bkaa084 |
| Popis: | Fluvoxamine is a selective serotonin reuptake inhibitor, with a half-life of about 30 hours, that is commonly prescribed in the treatment of depression and obsessive and compulsive disorders. Though its more favorable adverse effect profile in comparison to tricyclic antidepressants, overdosages could lead to severe central nervous system depression. We hereby report the case of a 48-year-old woman with psychiatric disorders, who died in the Protected Community where she lived. An autopsy, during which multiorgan congestion and aspiration of gastric content were found, was performed 9 days after the death. Femoral and cardiac blood, urine and bile were collected for toxicological analysis. GC–MS, LC–MS-MS and LC–HRMS screenings were performed on blood samples. The analysis allowed to identify the following drugs: fluvoxamine, clotiapine, 7-aminoclonazepam, propranolol, gabapentin and haloperidol. Quantification of the detected drugs in blood was performed by means of a validated LC–MS-MS analytical procedure, and the following results were achieved: fluvoxamine (2.20 mg/L), gabapentin (41.00 mg/L), 7-aminoclonazepam (0.24 mg/L), clotiapine (0.07 mg/L), haloperidol ( |
| Databáze: | OpenAIRE |
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