Rectal epithelial gamma/delta T-lymphocyte responses to local gluten challenge in coeliac disease
| Autor: | Paul J. Ciclitira, D. Loft, Michael N. Marsh, R. P. Sturgess, Peter T. Crowe, M Kontakou |
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| Rok vydání: | 1993 |
| Předmět: |
Adult
Male medicine.medical_specialty Glutens CD3 T-Lymphocytes chemical and pharmacologic phenomena digestive system Coeliac disease Epithelium T-Lymphocyte Subsets Internal medicine Immunopathology medicine Humans Intestinal Mucosa Receptor Aged chemistry.chemical_classification biology business.industry T-cell receptor Gastroenterology Rectum nutritional and metabolic diseases hemic and immune systems Receptors Antigen T-Cell gamma-delta T lymphocyte Middle Aged medicine.disease Gluten digestive system diseases Celiac Disease Endocrinology chemistry Immunology biology.protein Intraepithelial lymphocyte Female business |
| Zdroj: | Scandinavian journal of gastroenterology. 28(9) |
| ISSN: | 0036-5521 |
| Popis: | Sturgess RP, Loft D, Kontakou M, Crowe P, Marsh MN, Ciclitira PJ. Rectal epithelial γ/δ T-lymphocyte responses to local gluten challenge in coeliac disease. Scand J Gastroenterol 1993;28:760-762.The proportion of intra-epithelial lymphocytes (IEL) that utilize the γ/δ form of the T-cell receptor (TCR) is increased in coeliac disease, but their function remains unexplained. The response of intraepithelial lymphocytes to rectal gluten challenge in coeliac and control subjects was studied after a rectal challenge of 2 g of Frazer's fraction III. A marked rise in CD3+ IEL occurred after challenge in the coeliac patients, peaking at 6 h and returning to normal by 48 h, with no significant changes in the γ/δ TCR+ IEL. The IEL did not significantly change after gluten challenge in the controls. Acute gluten challenge induces infiltration of the rectal mucosa by T cells in coeliac patients, which is not accompanied acutely by increased numbers of γ/δ TCR+ IEL. This study supports the hypothesis that α/β TCR+ T ce... |
| Databáze: | OpenAIRE |
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