Inhibition of cAMP-phosphodiesterase by molybdate
| Autor: | Karl Eisele, Beatus Ofenloch-Hähnle |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
chemistry.chemical_classification
Molybdenum Molar concentration Chemistry Sodium molybdate Inorganic chemistry Phosphodiesterase Molybdate General Biochemistry Genetics and Molecular Biology 5'-nucleotidase Nucleotidases chemistry.chemical_compound Kinetics Enzyme 3' 5'-Cyclic-AMP Phosphodiesterases Nucleotidase Indicators and Reagents 5'-Nucleotidase Nuclear chemistry |
| Zdroj: | Zeitschrift fur Naturforschung. C, Journal of biosciences. 42(1-2) |
| ISSN: | 0939-5075 |
| Popis: | Inhibition of 3′:5′-cyclic-AMP-5′-nucleotidohydrolase (EC 3.1.4.17) type II (cAMP-phosphodiesterase) by sodium molybdate was studied: While determination of inorganic phosphate and 5′-ribonucleotide phosphohydrolase (5′-nucleotidase) (EC 3.1.3.5) activity was not disturbed by sodium molybdate in concentrations up to 10 mM , cAMP-phosphodiesterase was inhibited by millimolar concentrations of molybdate. The half maximal effect was observed at about 2 mM sodium molybdate (0.75 mM cAMP in the assay). |
| Databáze: | OpenAIRE |
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