Prevalence of SARS-CoV-2 in an area of unrestricted viral circulation: Mass seroepidemiological screening in Castiglione d'Adda, Italy
| Autor: | Bruno Alessandro Rivieccio, Giuseppe Marano, Patrizia Boracchi, Dario Bernacchia, Cosimo Ottomano, Silvana Castaldi, Giacomo Buonanno, Vittore F. Scolari, Elia Biganzoli, Cecilia Eugenia Gandolfi, Camilla Caimi, Federico Conti, Andrea Giacomelli, Arianna Rizzo, Massimo Galli, Andrea Prina, Martina Beltrami, Gabriele Pagani, Rossana Rondanin |
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| Přispěvatelé: | Università degli Studi di Milano [Milano] (UNIMI), Institut Curie [Paris], Centre National de la Recherche Scientifique (CNRS), Sorbonne Université - Faculté de Médecine (SU FM), Sorbonne Université (SU), Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico |
| Rok vydání: | 2020 |
| Předmět: |
Male
Pulmonology Cross-sectional study Artificial Gene Amplification and Extension Cardiovascular Medicine Logistic regression Antibodies Viral Polymerase Chain Reaction Vascular Medicine Biochemistry Persistence (computer science) 0302 clinical medicine Medical Conditions Medicine 050207 economics MESH: Immunoglobulin G education.field_of_study Mediolanum MESH: Immunoglobulin M 3. Good health Italy Cardiovascular Diseases SARS CoV 2 medicine.medical_specialty Science education Immunology Microbiology 03 medical and health sciences MESH: Cross-Sectional Studies 0502 economics and business Humans MESH: SARS-CoV-2 Molecular Biology Techniques Molecular Biology MESH: Prevalence Medicine and health sciences MESH: Humans Organisms Proteins Covid 19 Reverse Transcriptase-Polymerase Chain Reaction 030104 developmental biology Cross-Sectional Studies MESH: Female MESH: Antibodies Viral 0301 basic medicine RNA viruses Viral Diseases Coronaviruses Physiology [SDV]Life Sciences [q-bio] Serology Immune Physiology Epidemiology Prevalence MESH: COVID-19 Mass Screening Coronary Heart Disease 030212 general & internal medicine Pathology and laboratory medicine Virus Testing 050208 finance Multidisciplinary Immune System Proteins Transmission (medicine) 05 social sciences Medical microbiology Infectious Diseases Viruses Female Pathogens Research Article SARS coronavirus Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Chronic Obstructive Pulmonary Disease Population Cardiology MESH: COVID-19 Serological Testing Research and Analysis Methods Antibodies COVID-19 Serological Testing Diagnostic Medicine Internal medicine Seroprevalence MESH: Mass Screening Entire population Biology and life sciences business.industry SARS-CoV-2 Viral pathogens MESH: Italy COVID-19 MESH: Male Microbial pathogens Immunoglobulin M Immunoglobulin G business |
| Zdroj: | PLoS ONE PLoS ONE, Public Library of Science, 2021, 16 (2), pp.e0246513. ⟨10.1371/journal.pone.0246513⟩ PLoS ONE, Vol 16, Iss 2, p e0246513 (2021) |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0246513⟩ |
| Popis: | Introduction: Castiglione D’Adda is one of the municipalities more precociously and severely affected by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) epidemic in Lombardy. With our study we aimed to understand the diffusion of the infection by mass serological screening. Methods: We searched for SARS-CoV-2 IgGs in the population on a voluntary basis using lateral flow immunochromatographic tests (RICT) on capillary blood (rapid tests). We then performed chemioluminescent serological assays (CLIA) and naso-pharyngeal swabs (NPS) in a randomized representative sample and in each subject with a positive rapid test. Factors associated with RICT IgG positivity were assessed by uni- and multivariable logistic regression models. Results: Out of the 4143 participants, 918 (22·2%) showed an RICT IgG positivity. In multivariable analysis, IgG positivity increases with age, with a significant non-linear effect (p=0·0404). We found 22 positive NPSs out of the 1330 performed. Conclusions: Albeit relevant, the IgG prevalence is lower than expected and suggests that a large part of the population remains susceptible to the infection. The observed differences in prevalence might reflect a different infection susceptibility by age group. A limited persistence of active infections (positive NPSs) could be found after several weeks after the epidemic peak in the area. Funding Statement: CISOM (Corpo Italiano di Soccorso dell'Ordine di Malta), FC Internazionale Milano, SFD s.p.a , Emporio Armani Olimpia Milano through donations to the Dipartimento di Scienze Biomediche e Cliniche (DIBIC) of the University of Milan and to Banca Mediolanum through donation to ASST FatebenefratelliSacco, Milano. Declaration of Interests: The authors declare no conflicts of interest. Ethics Approval Statement: The study was approved by University of Milan’s Ethical Committee. |
| Databáze: | OpenAIRE |
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