Combined and individual use of pancaspase inhibitor Q-VD-OPh and NMDA receptor antagonist Riluzole in experimental spinal cord injury
| Autor: | Muhittin Emre Altunrende, Burcu Göker, Müge Dolgun, Cengiz Gomleksiz, Aydin Aydoseli, Halil Can, Altay Sencer |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Necrosis medicine.drug_class Apoptosis Inflammation Neuroprotection Amino Acid Chloromethyl Ketones Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine medicine Animals Spinal cord injury Spinal Cord Injuries Riluzole business.industry medicine.disease Receptor antagonist Spinal cord Rats Disease Models Animal Neuroprotective Agents 030104 developmental biology Anesthesiology and Pain Medicine medicine.anatomical_structure Anesthesia Quinolines Emergency Medicine NMDA receptor Surgery medicine.symptom business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Turkish Journal of Trauma and Emergency Surgery. |
| ISSN: | 1306-696X |
| DOI: | 10.5505/tjtes.2017.09694 |
| Popis: | Background We investigated the effects of an N-methyl-D-aspartate receptor antagonist, riluzole, and a pancaspase inhibitor and basic apoptosis mediator, Q-VD-OPh, in combination or alone in posttraumatic spinal cord injury. Methods In our study, 45 healthy male Sprague Dawley rats were used. Spinal trauma was induced by the clip compression technique via thoracal 7, 8, 9 laminectomies. After inducing the trauma, the drug was continuously administered intraperitoneally for 5 days. After inducing the trauma, the subjects were assessed using Tarlov's motor grading scale and inclined plane test. Five days after the trauma, the spinal cord specimens were harvested, and a histopathological examination was performed. Results Compared with the other groups, a statistically significant difference with regard to better results for necrosis, inflammation, and apoptosis was observed in the riluzole only and combination groups. Statistically better motor function scores were observed in the Q-VD-OPh only group than in the other groups. Conclusion With regard to limiting secondary damage after trauma, statistically significant results were observed in the Q-VDOPh only and Q-VD-OPh-riluzole combination groups. More extensive laboratory studies are required to limit and control the effects of secondary damage after spinal cord trauma. |
| Databáze: | OpenAIRE |
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