In-vitro studies on antioxidant and antidiabetic potential of Sesoot (Garcinia picrorrhiza Miq.) fruit ethanolic extract from Indonesia
| Autor: | Wahyu Widowati, Susi Endrini, Betharie Cendera Arrahmani, Hanna Sari Widya Kusuma, Sri Puji Utami, Qomariyah Sachrowardi, Dewi Nurul Mustaqimah, Sonny Pamuji Laksono, Said Nafik, Ndaru Andri Damayanti |
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| Rok vydání: | 2021 |
| Předmět: |
Cultural Studies
Linguistics and Language History antioxidant Antioxidant medicine.medical_treatment Language and Linguistics chemistry.chemical_compound Pharmacy and materia medica Diabetes mellitus Xanthone medicine Picrorrhiza Garcinia Natural medicine ABTS biology Traditional medicine antidiabetic Chemistry biology.organism_classification medicine.disease In vitro RS1-441 xanthone Anthropology garcinia picrorrhiza |
| Zdroj: | Pharmaciana, Vol 11, Iss 2, Pp 273-282 (2021) |
| ISSN: | 2477-0256 2088-4559 |
| DOI: | 10.12928/pharmaciana.v11i2.20110 |
| Popis: | Diabetes mellitus (DM) is a disease that can be identified by high levels of blood glucose. Garcinia plants have been widely used for many traditional medicines as antioxidant, anticancer, antidiabetics, and antiinflammation. The antioxidant and antidiabetic activities of ( Garcinia picrorrhiza Miq.) or sesoot fruit extract were evaluated in this study and compared with xanthone. The antioxidant and antidiabetic of ethanolic ripe sesoot ( G. picrorrhiza Miq.) fruit extract (GpKar) was evaluated by (ABTS) reducing activity, α-glucosidase, β-glucosidase, and α-amylase inhibitor activity. GpKar showed higher ABTS-reducing activity (IC 50 = 49.30 µg/mL) than xanthone (IC 50 = 404.30 µg/mL). GpKar showed IC 50 = 109.32 µg/mL for α-glucosidase inhibitory activity, while xanthones had a better activity (IC 50 = 33.97 µg/mL). GpKar also showed lower α-amylase inhibitory activity and β-glucosidase (IC 50 = 126.01 and 9432.09 µg/mL) compared to xanthone (IC 50 = 44.32 and 405.03 µg/mL, respectively). The compounds of GpKar are proven to have antioxidant and antidiabetic activities. Therefore, it will be industrially relevant to develop a natural medicine for decreasing DM risk, thus evaluating the antioxidant and antidiabetic effect of G. picrorrhiza by a pre-clinic study is needed. |
| Databáze: | OpenAIRE |
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