Alkaline phosphatase and phosphotyrosine phosphatase activities of cultured amniotic cells with trisomy 18
| Autor: | A. Brisson-Lougarre, Bourrouillou G, H. Vergnes, Colombies P, Grozdea J |
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| Rok vydání: | 1992 |
| Předmět: |
Amniotic fluid
Phosphatase Trisomy Protein tyrosine phosphatase Biochemistry Pregnancy Reference Values medicine Humans chemistry.chemical_classification biology medicine.disease Alkaline Phosphatase Amniotic Fluid Molecular biology Enzyme assay Enzyme chemistry Cell culture Pregnancy Trimester Second biology.protein Amniocentesis Alkaline phosphatase Female Protein Tyrosine Phosphatases Chromosomes Human Pair 18 |
| Zdroj: | Enzyme. 46(6) |
| ISSN: | 0013-9432 |
| Popis: | In cultured amniotic cells from fetuses with Edward's syndrome (trisomy 18), the activities of two protein phosphatases, alkaline phosphatase and phosphotyrosine phosphatase, were measured. Comparison with normal fetal cells showed a different behavior for each enzyme. Alkaline phosphatase was significantly lowered while phosphotyrosine phosphatase remained at normal levels. The interest of these enzyme assays in the screening procedure of this severe chromosome defect is discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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