Supplemental Methods and Supplemental Figures S1-S3 from KIT-Dependent and KIT-Independent Genomic Heterogeneity of Resistance in Gastrointestinal Stromal Tumors — TORC1/2 Inhibition as Salvage Strategy

Autor: Sebastian Bauer, Jonathan A. Fletcher, Stefan Fröhling, Peter Hohenberger, Peter Horak, Benedikt Brors, Albrecht Stenzinger, Hanno Glimm, Hans-Ulrich Schildhaus, Thomas Herold, Stefanie Bertram, Karl Worm, Jürgen Treckmann, Eva Wardelmann, Wolfgang Hartmann, Marcel Trautmann, Adrian Marino-Enriquez, Susanne Grunewald, Michael C. Heinrich, Julia Ketzer, Thomas Mühlenberg
Rok vydání: 2023
DOI: 10.1158/1535-7163.22510395.v1
Popis: Supplemental Methods; Supplemental Figure S1: Cancer-related mutations in the DKTK-Master patient cohort; Supplemental Figure S2: T1-PTEN cells were treated with increasing concentrations of approved KIT-inhibitors for 72h and analyzed by SRB assay; Supplemental Figure S3: Dose-combination studies with sapanisertib
Databáze: OpenAIRE