Early growth characteristics and the risk of reduced lung function and asthma: A meta-analysis of 25,000 children
| Autor: | Leone C A Craig, Claudia E. Kuehni, Liesbeth Duijts, Jordi Sunyer, Johan C. de Jongste, Hans Bisgaard, S. Hasan Arshad, Claudia Flexeder, Maria Vassilaki, Urs Frey, Irwin K M Reiss, Caroline Beardsmore, Erik Melén, Davide Gori, Alet H. Wijga, Anne C. van der Gugten, Agnes M.M. Sonnenschein-van der Voort, C. Kors van der Ent, Jesús Ibarluzea, Ana Esplugues, Carlos Zabaleta, Herman T. den Dekker, Francesco Forastiere, Henrique Barros, Monique Mommers, Anne Schmidt, Thomas Keil, Hazel Inskip, John Penders, A. John Henderson, Sofia Correia Phar, Vincent W. V. Jaddoe, Holger Schulz, Maria Pia Fantini, Matias Torrent, Daniela Porta, Katy Pike, Ulrike Gehring, Isabella Anessi-Maesano, Graham Devereux, Erica S. Schultz, Susanne Lau, Eva Morales, Manolis Kogevinas, Eskil Kreiner-Møller, Barbara Heude, Graham Roberts |
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| Přispěvatelé: | Den Dekker, Herman T., Sonnenschein-Van Der Voort, Agnes M.M., De Jongste, Johan C., Anessi-Maesano, Isabella, Arshad, S. Hasan, Barros, Henrique, Beardsmore, Caroline S., Bisgaard, Han, Phar, Sofia Correia, Craig, Leone, Devereux, Graham, Van Der Ent, C. Kor, Esplugues, Ana, Fantini, Maria P., Flexeder, Claudia, Frey, Ur, Forastiere, Francesco, Gehring, Ulrike, Gori, Davide, Van Der Gugten, Anne C., Henderson, A. John, Heude, Barbara, Ibarluzea, Jesú, Inskip, Hazel M., Keil, Thoma, Kogevinas, Manoli, Kreiner-Møller, Eskil, Kuehni, Claudia E., Lau, Susanne, Mélen, Erik, Mommers, Monique, Morales, Eva, Penders, John, Pike, Katy C., Porta, Daniela, Reiss, Irwin K., Roberts, Graham, Schmidt, Anne, Schultz, Erica S., Schulz, Holger, Sunyer, Jordi, Torrent, Matia, Vassilaki, Maria, Wijga, Alet H., Zabaleta, Carlo, Jaddoe, Vincent W.V., Duijts, Liesbeth, LS IRAS EEPI ME (Milieu epidemiologie), dIRAS RA-2, RS: CAPHRI - R5 - Optimising Patient Care, Epidemiologie, Medische Microbiologie, RS: CAPHRI - R4 - Health Inequities and Societal Participation, RS: NUTRIM - R2 - Gut-liver homeostasis, Epidemiology, Erasmus MC other, Pediatrics |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Vital capacity
Pediatrics Vital Capacity CHILDHOOD Diseases Infant Premature Diseases Weight Gain meta-analysi 0302 clinical medicine AIRWAY FUNCTION Child Development Models Risk Factors Forced Expiratory Volume Immunology and Allergy Respiratory function 030212 general & internal medicine 610 Medicine & health Non-U.S. Gov't Child Lung infant growth medicine.diagnostic_test RESPIRATORY-FUNCTION Research Support Non-U.S. Gov't Gestational age Statistical respiratory system ADOLESCENCE Child Preschool Infant Small for Gestational Age medicine.symptom 360 Social problems & social services Infant Premature Spirometry medicine.medical_specialty Adolescent Birth weight Immunology Gestational Age Research Support OBSTRUCTIVE PULMONARY-DISEASE 03 medical and health sciences FEV1/FVC ratio AGE children medicine Journal Article Humans low birth weight Preschool Premature Models Statistical business.industry Infant Newborn Infant lung function Preterm birth Odds ratio asthma Newborn SPIROMETRY BIRTH-WEIGHT Asthma respiratory tract diseases Low birth weight Preterm Birth Children Infant Growth Low Birth Weight Lung Function Meta-analysis 030228 respiratory system Small for Gestational Age MEASUREMENT ERROR business Meta-Analysis |
| Zdroj: | Journal of Allergy and Clinical Immunology, 137(4), 1026. Mosby Inc. Journal of Allergy and Clinical Immunology, 137(4), 1026-1035. MOSBY-ELSEVIER Journal of Allergy and Clinical Immunology, 137(4), 1026–1035. Mosby Inc. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY r-FISABIO. Repositorio Institucional de Producción Científica instname r-FISABIO: Repositorio Institucional de Producción Científica Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO) J. Allergy Clin. Immunol. 137, 1026-1035 (2016) Journal of Allergy and Clinical Immunology, 137(4), 1026-1035. Mosby Inc. |
| ISSN: | 0091-6749 |
| Popis: | Background: Children born preterm or with a small size for gestational age are at increased risk for childhood asthma. Objective: We sought to assess the hypothesis that these associations are explained by reduced airway patency. Methods: We used individual participant data of 24,938 children from 24 birth cohorts to examine and meta-analyze the associations of gestational age, size for gestational age, and infant weight gain with childhood lung function and asthma (age range, 3.9-19.1 years). Second, we explored whether these lung function outcomes mediated the associations of early growth characteristics with childhood asthma. Results: Children born with a younger gestational age had a lower FEV1, FEV1/forced vital capacity (FVC) ratio, and forced expiratory volume after exhaling 75% of vital capacity (FEF75), whereas those born with a smaller size for gestational age at birth had a lower FEV1 but higher FEV1/FVC ratio (P < .05). Greater infant weight gain was associated with higher FEV1 but lower FEV1/FVC ratio and FEF75 in childhood (P < .05). All associations were present across the full range and independent of other early-life growth characteristics. Preterm birth, low birth weight, and greater infant weight gain were associated with an increased risk of childhood asthma (pooled odds ratio, 1.34 [95% CI, 1.15-1.57], 1.32 [95% CI, 1.07-1.62], and 1.27 [95% CI, 1.21-1.34], respectively). Mediation analyses suggested that FEV1, FEV1/FVC ratio, and FEF75 might explain 7% (95% CI, 2% to 10%) to 45% (95% CI, 15% to 81%) of the associations between early growth characteristics and asthma. Conclusions: Younger gestational age, smaller size for gestational age, and greater infant weight gain were across the full ranges associated with childhood lung function. These associations explain the risk of childhood asthma to a substantial extent. |
| Databáze: | OpenAIRE |
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