In Vitro and In Vivo Lung Deposition of Coated Magnetic Aerosol Particles
| Autor: | P. Worth Longest, Timothy S. Wiedmann, Jian-Ping Wang, Yun Hao Xu, Yuanyuan Xie |
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| Rok vydání: | 2010 |
| Předmět: |
Materials science
Depot Pharmaceutical Science Nanoparticle Nanotechnology Ferric Compounds Magnetics Mice chemistry.chemical_compound Administration Inhalation Animals Tissue Distribution Particle Size Microparticle Lung Magnetite Aerosols respiratory system Aerosol Trachea Deposition (aerosol physics) Chemical engineering chemistry Nanoparticles Female Particle size Oleic Acid Superparamagnetism |
| Zdroj: | Journal of Pharmaceutical Sciences. 99:4658-4668 |
| ISSN: | 0022-3549 |
| Popis: | The magnetic induced deposition of polydispersed aerosols composed of agglomerated superparamagnetic particles was measured with an in vitro model system and in the mouse trachea and deep lung for the purpose of investigating the potential of site specific respiratory drug delivery. Oleic acid coated superparamagnetic particles were prepared and characterized by TEM, induced magnetic moment, and iron content. The particles were dispersed in cyclohexane, aerosolized with an ultrasonic atomizer and dried by sequential reflux and charcoal columns. The fraction of iron deposited on glass tubes increased with particle size and decreasing flow rate. High deposition occurred with a small diameter tube, but the deposition fraction was largely independent of tube size at larger diameters. Results from computational fluid dynamics qualitatively agreed with the experimental results. Enhanced deposition was observed in the mouse lung but not in the trachea consistent with the analysis of the aerodynamic time allowed for deposition and required magnetic deposition time. |
| Databáze: | OpenAIRE |
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