Synthesis and antibacterial activity of 6- and 7- (2-(5-carboxyimidazole-4-carboxamido)phenylacetamido)-penicillins and cephalosporins
| Autor: | Hisao Iwagami, Teizo Murata, Eiji Nakanishi, Naohiko Yasuda, Teruaki Nakamiya, Yukio Sasaki |
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| Rok vydání: | 1983 |
| Předmět: |
Male
medicine.drug_class Antibiotics Cephalosporin Microbial Sensitivity Tests Penicillins Microbiology Mice chemistry.chemical_compound Pseudomonas Ampicillin Amide Drug Discovery Escherichia coli medicine Animals Serratia marcescens Pharmacology Cephaloglycin Bacteria biology Chemistry Proteus biology.organism_classification Combinatorial chemistry Cephalosporins Klebsiella pneumoniae Antibacterial activity medicine.drug |
| Zdroj: | The Journal of Antibiotics. 36:242-249 |
| ISSN: | 1881-1469 0021-8820 |
| DOI: | 10.7164/antibiotics.36.242 |
| Popis: | The synthesis and antibacterial activity of a series of beta-lactam antibiotics having a 5-carboxyimidazole-4-carbonyl group attached through an amide linkage to ampicillin, cephaloglycin or their analogs are described. Some compounds of this series were found to possess high activity against Pseudomonas and other Gram-negative bacteria. |
| Databáze: | OpenAIRE |
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