ACCUMULATION AND DISTRIBUTION OF URANIUM IN RATS AFTER CHRONIC EXPOSURE BY INGESTION

Autor: P. Houpert, Eric Blanchardon, Patrick Gourmelon, Voisin Na, François Paquet, Christophe Maubert, Sandrine Frelon, A M. Moreels, O Delissen, B. Dhieux
Přispěvatelé: Laboratoire de radiotoxicologie et radiobiologie expérimentale (LRTOX), Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Laboratoire d'évaluation de la dose interne (DRPH/SDI/LEDI), Radiobiologie et épidémiologie (DRPH/SRBE)
Rok vydání: 2006
Předmět:
Male
Dose calculation
Epidemiology
urinalysis
[SDV]Life Sciences [q-bio]
Health
Toxicology and Mutagenesis
tissue distribution
experimental model
oral drug administration
Administration
Oral
dose calculation
acute toxicity
010501 environmental sciences
01 natural sciences
Rats
Sprague-Dawley
Models
toxicokinetics
Ingestion
mineralization
rat
animal
rat strain
tooth
mineral water
comparative study
0303 health sciences
Sprague Dawley rat
Chemistry
article
Contamination
Uranium
radioactive contamination
urine
phosphorescence
bioaccumulation
priority journal
isotope dilution assay
uranyl nitrate
Administration
Oral
Chronic exposure
brain
animal experiment
chemistry.chemical_element
Models
Biological
animal tissue
long term exposure
03 medical and health sciences
radioisotope distribution
Animalia
Animals
Distribution (pharmacology)
controlled study
Radiology
Nuclear Medicine and imaging
030304 developmental biology
0105 earth and related environmental sciences
Radionuclide
nonhuman
animal model
Radiochemistry
tissue
weight
euthanasia
prediction
biological model
Biological
Rats
ingestion
Sprague-Dawley
chronic toxicity
Zdroj: Health Physics
Health Physics, 2006, 90 (2), pp.139-147. ⟨10.1097/01.HP.0000174527.66111.83⟩
ISSN: 0017-9078
Popis: Data describing the biokinetics of radionuclides after contamination come mainly from experimental acute exposures of laboratory animals and follow-up of incidental exposures of humans. These data were compiled to form reference models that could be used for dose calculation in humans. In case of protracted exposure, the same models are applied, assuming that they are not modified by the duration of exposure. This work aims at testing this hypothesis. It presents new experimental data on retention of uranium after chronic intake, which are compared to values calculated from a biokinetic model that is based on experiments of acute exposure of rats to uranium. Experiments were performed with 56 male Sprague Dawley rats, from which 35 were exposed during their whole adult life to 40 mg L-1 of uranyl nitrate dissolved in mineral water and 21 were kept as controls. Animals were euthanatized at 32, 95, 186, 312, 368, and 570 d after the beginning of contamination. Urine and all tissues were removed, weighted, mineralized, and then analyzed for uranium content by Kinetics Phosphorescence Analysis (KPA) or by ICP-MS. Experimental data showed that uranium accumulated in most organs, following a nonmonotonous pattern. Peaks of activities were observed at 1-3, 10, and 19 mo after the beginning of exposure. Additionally, accumulation was shown to occur in tissues such as teeth and brain that are not usually described as target organs. Comparison with model prediction showed that the accumulation of uranium in target organs after chronic exposure is overestimated by the use of a model designed for acute exposure. These differences indicate that protracted exposure to uranium may induce changes in biokinetic parameters when compared to acute contamination and that calculation of dose resulting from chronic intake of radionuclides may need specific models that are not currently available. Copyright © 2006 Health Physics Society.
Databáze: OpenAIRE
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