Successful Treatment With a Chimeric Anti-CD20 Monoclonal Antibody (IDEC-C2B8, Rituximab) for a Patient With Relapsed Mantle Cell Lymphoma Who Developed a Human Anti-Chimeric Antibody
Autor: | Yasuaki Yamada, Masayuki Tawara, Yuichi Yakata, Masao Tomonaga, Takahiro Maeda, S Kamihira, Reishi Yamasaki, Chizuko Tsutsumi, Yasuyuki Onimaru |
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Rok vydání: | 2001 |
Předmět: |
Enzyme-Linked Immunosorbent Assay
Lymphoma Mantle-Cell Antibodies Monoclonal Murine-Derived Antigen Antigens Neoplasm hemic and lymphatic diseases Antineoplastic Combined Chemotherapy Protocols Humans Medicine Lymphocyte Count Aged CD20 biology business.industry Antibodies Monoclonal Human anti-chimeric antibody Hematology Antigens CD20 medicine.disease Drug Resistance Multiple Antibodies Anti-Idiotypic Lymphoma Drug Resistance Neoplasm Immunology Monoclonal biology.protein Female Tracheal Neoplasms Mantle cell lymphoma Rituximab Immunotherapy Neoplasm Recurrence Local Antibody business medicine.drug |
Zdroj: | International Journal of Hematology. 74:70-75 |
ISSN: | 1865-3774 0925-5710 |
Popis: | Mantle cell lymphoma (MCL) has a poor prognosis without cure; the median overall survival ranges only from 3 to 4 years irrespective of conventional therapeutic regimens. IDEC-C2B8 (rituximab), a chimeric monoclonal antibody against the B-cell—specific antigen CD20, induces an evaluable clinical response in patients with MCL with mild toxicities. However, the single agent rituximab cannot cure MCL. Due to its low immunogenicity, an antibody against IDEC-C2B8 (human anti-chimeric antibody [HACA]) has rarely been produced in vivo. We report a patient with relapsed MCL who was successfully treated with IDEC-C2B8 for over a year although she developed HACA 6 months after the initial administration of IDEC-C2B8 in the phase II clinical trial conducted by Zenyaku Kogyo Co. Ltd. We followed the pharmacokinetics of IDEC-C2B8, the serum HACA titer, and the number of B lymphocytes in the peripheral blood in relation to clinical response. The HACA became undetectable soon after subsequent administrations of IDEC-C2B8. When the serum level of IDEC-C2B8 was kept elevated, clinical responses were apparently observed and HACA disappeared during this response period. There were no significant clinical toxicities related to the appearance of HACA. The present findings suggested that IDEC-C2B8 is effective and safe even in patients who have developed HACA. |
Databáze: | OpenAIRE |
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