Simple practical method for synthesis of trisubstituted imidazoles: an efficient copper catalyzed multicomponent reaction

Autor:	Ganesh A. Mali, Siddheshwar P. Khadul, Vikas D. Kadu, Gokul J. Kothe
Rok vydání:	2021
Předmět:	010405 organic chemistry General Chemical Engineering Substrate (chemistry) General Chemistry 010402 general chemistry 01 natural sciences Combinatorial chemistry 0104 chemical sciences Catalysis chemistry.chemical_compound chemistry Benzoin Copper catalyzed Benzil Nitrogen source Ammonium acetate
Zdroj:	RSC Advances. 11:21955-21963
ISSN:	2046-2069
DOI:	10.1039/d1ra01767e
Popis:	A rapid practical process has been developed for synthesis of 2,4,5-trisubstituted-imidazoles in excellent yields up to 95% from readily available starting materials. In this CuI catalyzed synthesis, trisubstituted imidazoles were afforded in short reaction times, wherein the substrate scope is well explored with benzoin as well as benzil reacting with different aldehydes in the presence of ammonium acetate as the nitrogen source.
Databáze:	OpenAIRE
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