Optical Coherence Tomography Angiography Macular and Peripapillary Vessel Perfusion Density in Healthy Subjects, Glaucoma Suspects, and Glaucoma Patients
| Autor: | Francesco Bandello, Federico Di Matteo, Nathan D. Shemonski, Ali Fard, Riccardo Sacconi, Giuseppe Querques, Alessandro Rabiolo, Stephanie Magazzeni, Piero Barboni, Paolo Bettin, Giacinto Triolo, Luis E Vazquez |
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| Přispěvatelé: | Triolo, Giacinto, Rabiolo, Alessandro, Shemonski, Nathan D., Fard, Ali, Di Matteo, Federico, Sacconi, Riccardo, Bettin, Paolo, Magazzeni, Stephanie, Querques, Giuseppe, Vazquez, Luis E., Barboni, Piero, Bandello, Francesco |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male Retinal Ganglion Cells Intraocular pressure genetic structures Computed Tomography Angiography Nerve fiber layer Glaucoma Perfusion scanning Retinal Ganglion Cell chemistry.chemical_compound 0302 clinical medicine Nerve Fibers Vessel perfusion density Visual Field Test Macula Lutea Prospective Studies Computed tomography angiography medicine.diagnostic_test Middle Aged Healthy Volunteer Retinal Vessel Healthy Volunteers medicine.anatomical_structure Nerve Fiber Optic nerve Female Glaucoma Open-Angle Tomography Optical Coherence Human medicine.medical_specialty Glaucoma suspect Perfusion Imaging Optic Disk 03 medical and health sciences Cellular and Molecular Neuroscience Optical coherence tomography Ophthalmology medicine Humans Intraocular Pressure business.industry Retinal Vessels Retinal medicine.disease eye diseases Optical coherence tomography angiography Prospective Studie 030104 developmental biology chemistry Regional Blood Flow 030221 ophthalmology & optometry Visual Field Tests Ocular Hypertension sense organs business Sensory System |
| Zdroj: | Investigative ophthalmologyvisual science. 58(13) |
| ISSN: | 1552-5783 |
| Popis: | PURPOSE. To evaluate macular and peripapillary vessel perfusion density (VD) in glaucoma suspects (GS) and glaucoma patients; to correlate ganglion cellâinner plexiform layer (GCIPL) and retinal nerve fiber layer (RNFL) thicknesses with macular and peripapillary VD; and to evaluate the diagnostic accuracy of the structural and vascular parameters. METHODS. A consecutive series of GS, glaucoma patients, and healthy subjects was prospectively recruited from July 1, 2016, to January 31, 2017. All subjects underwent standard automated perimetry, spectral-domain optical coherence tomography (OCT), and 6 à 6-mm optical coherence tomography angiography (OCT-A) centered on the fovea and optic nerve. RESULTS. Forty controls, 40 GS, and 40 glaucoma patients were enrolled. Peripapillary RNFL, GCIPL, and macular RNFL thicknesses significantly decreased in the glaucoma group compared to controls and GS (P < 0.01). Peripapillary VD in average and in the superior and inferior quadrants decreased in the glaucoma group (P ⤠0.001); conversely, macular VD was not statistically different across groups (P > 0.05). At the peripapillary area, a correlation between RNFL thickness and VD was found; conversely, no statistically significant correlation was found between GCIPL thicknesses and macular VD (all P > 0.05) in all groups. Peripapillary RNFL and GCIPL showed higher diagnostic capacity compared to peripapillary and macular VDs. CONCLUSIONS. Structural damage is evident both in the peripapillary and in macular areas. Vascular damage seems to be less prominent, as it was seen only for the glaucoma group and at the radial peripapillary plexus. Diagnostic abilities are excellent for structural variables, less so but still good for peripapillary VD, and poor for macular VD. |
| Databáze: | OpenAIRE |
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