Ire1 regulated XBP1 mRNA splicing is essential for the unfolded protein response (UPR) in Drosophila melanogaster
| Autor: | Nongluk Plongthongkum, Niwed Kullawong, Sakol Panyim, Witoon Tirasophon |
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| Rok vydání: | 2007 |
| Předmět: |
Saccharomyces cerevisiae Proteins
XBP1 RNA Splicing Biophysics Endoplasmic Reticulum Biochemistry Endoribonucleases Protein biosynthesis Animals Drosophila Proteins Molecular Biology Cells Cultured Base Sequence biology Schneider 2 cells Endoplasmic reticulum fungi Cell Biology biology.organism_classification Cell biology DNA-Binding Proteins Oxidative Stress Drosophila melanogaster RNA splicing Unfolded protein response Signal transduction Molecular Chaperones |
| Zdroj: | Biochemical and Biophysical Research Communications. 354:789-794 |
| ISSN: | 0006-291X |
| Popis: | The ability of cells to survive and recover from deteriorating effects of endoplasmic reticulum (ER) stress relies on the unfolded protein response (UPR). The signaling pathway of Ire1p mediate mRNA splicing plays diverge role in UPR response in different organisms from yeast to mammals. Here, we report that Ire1p mediated XBP1 mRNA splicing mechanism is extremely conserved and exerts a critical role for modulating Xbp1 protein synthesis in Drosophila melanogaster. This system is operative in Drosophila S2 cells as a prominent mechanism to mediate transcriptional activation of UPR responsive genes during ER stress. |
| Databáze: | OpenAIRE |
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