IL-1R signaling in dendritic cells replaces pattern-recognition receptors in promoting CD8+ T cell responses to influenza A virus
| Autor: | Iris K. Pang, Akiko Iwasaki, Takeshi Ichinohe |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Priming (immunology)
CD8-Positive T-Lymphocytes Lymphocyte Activation migration medicine.disease_cause Mice 0302 clinical medicine Cell Movement Influenza A virus Immunology and Allergy Cytotoxic T cell Mice Knockout 0303 health sciences Membrane Glycoproteins respiratory mucosa Pattern recognition receptor virus diseases Cell Differentiation 3. Good health Receptors Pattern Recognition monocytes Signal Transduction Receptors CCR7 Immunology Antigen presentation Nerve Tissue Proteins Receptors Cell Surface Biology Article 03 medical and health sciences Immune system Orthomyxoviridae Infections inflammasome medicine Animals 030304 developmental biology Innate immune system Membrane Proteins Receptors Interleukin-1 Dendritic Cells Virology Mice Inbred C57BL Toll-Like Receptor 7 viral immunity Myeloid Differentiation Factor 88 CD8 Interleukin-1 030215 immunology |
| Zdroj: | Nature immunology |
| ISSN: | 1529-2916 1529-2908 |
| DOI: | 10.1038/ni.2514 |
| Popis: | Immune responses to vaccines require direct recognition of pathogen-associated molecular patterns (PAMPs) through pattern-recognition receptors (PRRs) on dendritic cells (DCs). Unlike vaccination, infection by a live pathogen often impairs DC function and inflicts additional damage on the host. Here we found that after infection with live influenza A virus, signaling through the interleukin 1 receptor (IL-1R) was required for productive priming of CD8(+) T cells, but signaling through the PRRs TLR7 and RIG-I was not. DCs activated by IL-1 in trans were both required and sufficient for the generation of virus-specific CD8(+) T cell immunity. Our data demonstrate a critical role for a bystander cytokine in the priming of CD8(+) T cells during infection with a live virus. |
| Databáze: | OpenAIRE |
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