Enteroaggregative Escherichia coli Subclinical Infection and Coinfections and Impaired Child Growth in the MAL-ED Cohort Study
| Autor: | Pablo Peñataro Yori, Estomih Mduma, Dennis Lang, Cláudia B. Abreu, Carl J. Mason, Francisco S Junior, Noélia L. Lima, Monica McGrath, Christopher Troeger, Herlice N. Veras, Aldo A. M. Lima, Erling Svensen, William K-Y Pan, Tahmeed Ahmed, Pascal O. Bessong, Eric R. Houpt, José Q. Filho, Alberto M. Soares, Alexandre Havt, Ila F. N. Lima, Ben J J McCormick, Shahida Qureshi, Gangadeep Kang, Michael Gottlieb, Elizabeth T. Rogawski, Jean Gratz, Sudhir Babji, Ladaporn Bodhidatta, Amidou Samie, Rosa Maria Salani Mota, Mara A Prata, Rashidul Haque, Margaret Kosek, Richard L. Guerrant, Sadia Shakoor, Shrestha Jasmin, Zulfigar A. Bhutta, James A Platts-Mills, Pedro H. Q. S. Medeiros |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Gut inflammation Male medicine.medical_specialty 030106 microbiology Cohort Studies 03 medical and health sciences Enteropathogenic Escherichia coli Feces Child Development Risk Factors Internal medicine medicine Humans Child growth Escherichia coli Infections Growth Disorders Subclinical infection Anthropometry business.industry Coinfection Gastroenterology Infant Nutritional status medicine.disease Intestines Malnutrition Enteroaggregative Escherichia coli Pediatrics Perinatology and Child Health Female Birth cohort business Cohort study Follow-Up Studies |
| Zdroj: | Journal of pediatric gastroenterology and nutrition. 66(2) |
| ISSN: | 1536-4801 |
| Popis: | We evaluated the impact of subclinical enteroaggregative Escherichia coli (EAEC) infection alone and in combination with other pathogens in the first 6 months of life on child growth.Nondiarrheal samples from 1684 children across 8 Multisite Birth Cohort Study, Malnutrition and Enteric Diseases (MAL-ED) sites in Asia, Africa, and Latin America were tested monthly; more than 90% of children were followed-up twice weekly for the first 6 months of life.Children with subclinical EAEC infection did not show altered growth between enrollment and 6 months. Conversely, EAEC coinfection with any other pathogen was negatively associated with delta weight-for-length (P 0.05) and weight-for-age (P 0.05) z scores between 0 and 6 months. The presence of 2 or more pathogens without EAEC was not significantly associated with delta weight-for-length and weight-for-age. The most frequent EAEC coinfections included Campylobacter spp, heat-labile toxin-producing enterotoxigenic E coli, Cryptosporidium spp, and atypical enteropathogenic E coli. Myeloperoxidase levels were increased with EAEC coinfection (P 0.05). EAEC pathogen codetection was associated with lower neopterin levels compared to those of no-pathogen control children (P 0.05). Mothers of children with EAEC coinfections had lower levels of education, poorer hygiene and sanitation, lower socioeconomic status, and lower breast-feeding rates compared to mothers of children in whom no pathogen was detected (P 0.05).These data emphasize the public health importance of subclinical EAEC infection in early infancy in association with other pathogens and the need for improved maternal and child care, hygiene, sanitation, and socioeconomic factors. |
| Databáze: | OpenAIRE |
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