Parameters for antimicrobial photodynamic therapy on periodontal pocket—Randomized clinical trial
| Autor: | Christiane Pavani, Anna Carolina Ratto Tempestini Horliana, Martha S. Ribeiro, Giovane Noschese, Sandra Kalil Bussadori, Daniela de Fátima Teixeira da Silva, Ilka Tiemy Kato, Letícia Heineck Alvarenga, Renato Araujo Prates, Mark Wainwright, Yhago Gazote Eloy Geraldo, Bianca Godoy-Miranda, Ana Carolina Gomes, Pamela Carribeiro |
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| Rok vydání: | 2019 |
| Předmět: |
Male
RM Time Factors Gingival and periodontal pocket Drug Compounding medicine.medical_treatment 030303 biophysics Biophysics Dentistry Photodynamic therapy Dermatology law.invention Surface-Active Agents 030207 dermatology & venereal diseases 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Randomized controlled trial law medicine Humans Periodontal Pocket Pharmacology (medical) Photosensitizer 0303 health sciences Photosensitizing Agents business.industry Antimicrobial medicine.disease Combined Modality Therapy Chronic periodontitis QR Methylene Blue Clinical trial Photochemotherapy Oncology chemistry Female Periodontal Index business Methylene blue |
| Zdroj: | Photodiagnosis and Photodynamic Therapy. 27:132-136 |
| ISSN: | 1572-1000 1873-1597 |
| DOI: | 10.1016/j.pdpdt.2019.05.035 |
| Popis: | BACKGROUND: Antimicrobial photodynamic therapy (aPDT) has been investigated as an adjunctive to periodontal treatment but the dosimetry parameters adopted have discrepancies and represent a challenge to measure efficacy. There is a need to understand the clinical parameters required to obtain antimicrobial effects by using aPDT in periodontal pockets. The aim of this study was to investigate parameters relating to the antimicrobial effects of photodynamic therapy in periodontal pockets. MATERIAL AND METHODS: This randomized controlled clinical trial included 30 patients with chronic periodontitis. Three incisors from each patient were selected and randomized for the experimental procedures. Microbiological evaluations were performed to quantify microorganisms before and after treatments and spectroscopy was used to identify methylene blue in the pocket. A laser source with emission of radiation at wavelength of ʎ = 660 nm and output radiant power of 100 mW was used for 1, 3 and 5 min. One hundred μM methylene blue was used in aqueous solution and on surfactant vehicle. RESULTS: The results demonstrated the absence of any antimicrobial effect with aqueous methylene blue-mediated PDT. On the other hand, methylene blue in the surfactant vehicle produced microbial reduction in the group irradiated for 5 min (p |
| Databáze: | OpenAIRE |
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