The role of polymorphonuclear leukocytes in delayed hypersensitivity skin reactions: suppressive effects of anti-polymorphonuclear leukocyte serum
| Autor: | Tadashi Nakamura, Takeshi Kambara, Tatsuomi Yasaka |
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| Rok vydání: | 1981 |
| Předmět: |
Polymorphonuclear leukocyte
Antiserum Male Time Factors business.industry Neutrophils Immune Sera Guinea Pigs Vascular permeability Guinea pig Capillary Permeability Skin reaction Leukocyte Count Mild depression Delayed hypersensitivity Cell Movement Peritoneal exudate Immunology Medicine Animals Hypersensitivity Delayed Rabbits business Skin |
| Zdroj: | Virchows Archiv. B, Cell pathology including molecular pathology. 37(2) |
| ISSN: | 0340-6075 |
| Popis: | Rabbit antisera (APS) against normal guinea pig peritoneal exudate polymorphonuclear leukocytes (PMN), when injected intraperitoneally three times within 24 h into guinea pigs, lead to a marked fall in the blood PMN count (below 100/mm3) 24-72 h after the injection and a mild depression in the number of circulating mononuclear leukocytes (MNC) at 36-72 h. APS treatment of guinea pigs led to a marked suppression of delayed hypersensitivity skin reactions in response to dinitrophenylated bovine gamma-globulin. The volume, induration, mean diameter of the reaction and leukocyte (both PMN and MNC) emigration into local sites were suppressed, as was, to a lesser extent, vascular permeability. Based on these observations it appears that circulating PMN are required for the full expression of delayed hypersensitivity reaction engendered by bovine gamma-globulin. |
| Databáze: | OpenAIRE |
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