Medical treatment in pregnant women with subclinical hypothyroidism: systematic review and meta-analysis
| Autor: | Katia Andrea Abuhadba-Cayao, Jesús E. Talavera, Víctor Juan Vera-Ponce, Jhony A. De La Cruz-Vargas |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Revista Brasileira de Saúde Materno Infantil v.22 n.2 2022 Revista Brasileira de Saúde Materno Infantil Instituto de Medicina Integral Prof. Fernando Figueira (IMIPFF) instacron:IMIPFF |
| Popis: | Objectives: to determine the effectiveness of medical therapy in reducing complications associated with subclinical hypothyroidism during pregnancy. Methods: in 2021, a systematic review of available cohort studies was carried out in three databases, with no publication date limit. Study selection and data extraction were performed in duplicate. Random-effects meta-analysis was performed, and odds ratios were calculated, with the corresponding 95% confidence intervals. Cohort risk of bias was assessed using the Newcastle-Ottawa Scale (NOS). The certainty of the evidence was assessed using the GRADE methodology. Results: five studies were included for qualitative and quantitative synthesis. A statistically significant relationship was found between medical treatment in pregnant women with subclinical hypothyroidism with respect to spontaneous abortion (p=0.03; OR=0.77; CI95%=0.61-0.97), and no statistically significant relationship was found for delivery preterm (p=0.46; OR=1.11; CI95%=0.85-1.44), nor for abrupt placentae (p=0.56; OR=1.60; CI95%=0.33-7.66). Three studies were at moderate risk of bias, and two were at low risk of bias. In all the results the certainty was very low. Conclusions: medical treatment of subclinical hypothyroidism during pregnancy can have a beneficial effect in reducing cases of spontaneous abortion. |
| Databáze: | OpenAIRE |
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