Investigation of amino acid containing [FeFe] hydrogenase models concerning pendant base effects
| Autor: | Enrico Morera, Johannes G. Vos, Wolfgang Weigand, Gino Lucente, Yvonne Halpin, Bernhard K. Keppler, Helmar Görls, Joachim Kübel, Ulf-Peter Apfel, Florian Kloss, Christian R. Kowol |
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| Rok vydání: | 2009 |
| Předmět: |
Iron-Sulfur Proteins
Models Molecular Magnetic Resonance Spectroscopy Hydrogenase Lysine chemistry.chemical_element Peptide Crystallography X-Ray Ligands Electrochemistry Biochemistry Medicinal chemistry Mass Spectrometry Inorganic Chemistry chemistry.chemical_compound Catalytic Domain Spectroscopy Fourier Transform Infrared Trifluoroacetic acid Organic chemistry chemistry.chemical_classification Molecular Structure Molecular Mimicry Sulfur Amino acid chemistry Biocatalysis Amine gas treating |
| Zdroj: | Journal of Inorganic Biochemistry. 103:1236-1244 |
| ISSN: | 0162-0134 |
| DOI: | 10.1016/j.jinorgbio.2009.07.005 |
| Popis: | The present investigations deal with the modeling of the peptide surrounding of [FeFe] hydrogenase using amine containing disulphides to simulate possible influences of the amino acid lysine (K237) on the electrochemical and electrocatalytic properties of biomimetic compounds based on [Fe2S2] moieties. Fe(3)(CO)(12) was reacted with Boc-4-amino-1,2-dithiolane, Boc-Adt-OMe (Adt=4-amino-1,2-dithiolane-4-carboxylic acid, Boc=tert-butoxycarbonyl) and Boc-Adp tert-butyl ester (Adp=(S)-2-amino-3-(1,2-dithiolan-4-yl)propionic acid) to elongate the Fecdots, three dots, centeredN distance in comparison to the well known [Fe(2){(SCH(2))(2)NR}(CO)(6)] model complexes. Efforts to deprotect the complexes containing Boc-4-amino-1,2-dithiolane with trifluoroacetic acid result in the formation of [Fe(3)(mu(3)-O)(mu-O(2)C(2)F(3))(6)(OC(4)H(8))(2)(H(2)O)]. The novel [2Fe2S] complexes are characterized using spectroscopic, electrochemical techniques and X-ray diffraction studies. |
| Databáze: | OpenAIRE |
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