Influence of the priming technique on pharmacodynamics and intubating conditions of cisatracurium
| Autor: | Debora B Martineau, Krishnaprasad Deepika, Charbel A Kenaan, George B. Bikhazi |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Adult
Time Factors Adolescent Priming (agriculture) Placebo law.invention Placebos Sufentanil Randomized controlled trial law Intubation Intratracheal medicine Humans Muscle Skeletal Ulnar Nerve Aged Thiopental Sodium business.industry Myography Middle Aged Anesthesiology and Pain Medicine Isoflurane Anesthesia Pharmacodynamics Anesthesia Recovery Period Anesthetics Inhalation Atracurium Neuromuscular Blockade Female Neuromuscular Blocking Agents business Droperidol Anesthetics Intravenous Preanesthetic Medication Adjuvants Anesthesia Muscle Contraction medicine.drug |
| Zdroj: | Journal of Clinical Anesthesia. 11:572-575 |
| ISSN: | 0952-8180 |
| DOI: | 10.1016/s0952-8180(99)00099-9 |
| Popis: | Study Objectives: To determine the effects of the priming technique on the intubating conditions and pharmacodynamics of different doses of cisatracurium. Design: Open-label, randomized study. Setting: Operating room of a university-affiliated hospital. Patients: 60 ASA physical status I, II, and III female patients. Interventions: Patients were randomly assigned to one of four groups. Patients from Groups 1, 2, and 3 received 0.01 mg/kg cisatracurium as a priming dose, and patients from Group 4 received placebo. Four minutes later, patients from Groups 1, 2, 3, and 4 received the following intubating doses of cisatracurium: 0.09 mg/kg, 0.14 mg/kg, 0.19 mg/kg, and 0.2 mg/kg, respectively. Anesthesia was induced with thiopental sodium, sufentanil, droperidol, and nitrous oxide (N 2 O; 6 L/min) in oxygen (O 2 ; 4 L/min) and maintained with isoflurane up to 0.7%, N 2 O in O 2 , and sufentanil. Mechanomyography assessed the neuromuscular function of the adductor pollicis with train-of-four supramaximal impulses. The trachea was intubated when the amplitude of the first twitch decreased to 10% to 15% of control. Measurements and Main Results: There were no significant differences among the groups regarding the demographic data, the value of the first twitch at 60 seconds, the time to 90% block, and the onset time. Clinical duration of cisatracurium was significantly different between Group 3 and Groups 1 and 2, whereas Group 4 differed significantly from Group 1. Intubating conditions did not differ significantly among the groups. Conclusion: When primed, cisatracurium 0.09 mg/kg and 0.14 mg/kg produced an onset time comparable with that of 0.2 mg/kg and allowed an earlier spontaneous recovery ( p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect