Ultrasound targeting of Q-starch/miR-197 complexes for topical treatment of psoriasis
| Autor: | Dror Avni, Yechezkel Sidi, Joseph Kost, Moti Harats, Ramesh Chintakunta, Rinat Lifshiz Zimon, Tamar Traitel, Moamen Masalha, Etili Hollander, Riki Goldbart, Galya Lerman, Aviv Barzilai, Tal Meningher, Einat Elharrar |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Starch Swine Administration Topical Skin Absorption Pharmaceutical Science Disease Mice SCID 03 medical and health sciences Therapeutic approach chemistry.chemical_compound Mice 0302 clinical medicine Drug Delivery Systems Psoriasis microRNA medicine Animals Humans Receptor Transdermal Drug Carriers Receptors Interleukin-17 business.industry Ultrasound Receptors Interleukin medicine.disease MicroRNAs 030104 developmental biology chemistry Ultrasonic Waves 030220 oncology & carcinogenesis Cancer research business |
| Zdroj: | Journal of controlled release : official journal of the Controlled Release Society. 284 |
| ISSN: | 1873-4995 |
| Popis: | Psoriasis is a common, worldwide autoinflammatory, incurable skin disease. miR-197 has therapeutic potential for psoriasis since it can down-regulate the expression of both IL-22RA1 and IL-17RA, subunits of the receptors of IL-22 and IL-17, respectively, which are key cytokines in the disease. Although miR-197 has the potential to treat the disease, several inherent physical barrier properties of the skin challenge miRNA's delivery to the target skin cells. In the present study, we evaluated a therapeutic approach that combines the use of ultrasound (US) as a means to enhance skin permeability with quaternized starch (Q-starch) as an miRNA delivery carrier. This resulted in decreased expression of the miR-197 target proteins and in a significant reduction in the psoriatic activity markers. Our results demonstrate the potential of combinations of US and Q-starch/miR-197 complexes for the topical skin treatment of psoriasis. |
| Databáze: | OpenAIRE |
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