Increased Radiation-Associated T-Cell Infiltration in Recurrent IDH-Mutant Glioma
| Autor: | Anastasia Makarevic, Andreas Unterberg, Andreas von Deimling, Christine Jungk, Rolf Warta, Steffen Dettling, Carmen Rapp, David E. Reuss, Amir Abdollahi, Christel Herold-Mende |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
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medicine.medical_treatment T-cell infiltration lcsh:Chemistry TissueFAXS Tumor Microenvironment Medicine Cytotoxic T cell lcsh:QH301-705.5 Spectroscopy Aged 80 and over Brain Neoplasms General Medicine Glioma Middle Aged Primary tumor Isocitrate Dehydrogenase Computer Science Applications Female Infiltration (medical) Adult primary tumors Matched-Pair Analysis Recurrent Glioma Catalysis Article Inorganic Chemistry Young Adult Lymphocytes Tumor-Infiltrating Humans recurrent tumors Physical and Theoretical Chemistry Molecular Biology radiotherapy Aged lower-grade glioma Chemotherapy business.industry Organic Chemistry Immunotherapy medicine.disease Radiation therapy lcsh:Biology (General) lcsh:QD1-999 Mutation Cancer research Neoplasm Recurrence Local business T-Lymphocytes Cytotoxic |
| Zdroj: | International Journal of Molecular Sciences, Vol 21, Iss 7801, p 7801 (2020) International Journal of Molecular Sciences Volume 21 Issue 20 |
| ISSN: | 1661-6596 1422-0067 |
| Popis: | Most gliomas are associated with a fatal prognosis and remain incurable because of their infiltrative growth. Consequently, the addition of immunotherapy to conventional therapy may improve patient outcomes. Here, we analyzed T-cell infiltration and, therefore, a major prerequisite for successful immunotherapy in a series of primary (n = 78) and recurrent (n = 66) isocitrate dehydrogenase (IDH)-mutant glioma and their changes following treatment with radio- and/or chemotherapy. After multicolor immunofluorescence staining, T cells were counted in entire tumor sections using a software-based setup. Newly diagnosed diffuse IDH-mutant gliomas displayed a median T-cell infiltration of 0.99 T cells/mm2 (range: 0&ndash 48.97 CD3+ T cells/mm2), which was about two-fold increased for CD3+, helper, and cytotoxic T cells in recurrent glioma. Furthermore, T-cell infiltration of recurrent tumors was associated with the type of adjuvant treatment of the primary tumor. Interestingly, only glioma patients solely receiving radiotherapy presented consistently with increased T-cell infiltration in their recurrent tumors. This was confirmed in a subset of 27 matched pairs. In conclusion, differences in the T-cell infiltration of primary and recurrent gliomas were demonstrated, and evidence was provided for a beneficial long-term effect on T-cell infiltration upon treatment with radiotherapy. |
| Databáze: | OpenAIRE |
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