Effect of Sleeve Gastrectomy Plus Side-to-Side Jejunoileal Anastomosis for Type 2 Diabetes Control in an Obese Rat Model
| Autor: | Jiangfan Zhu, Jiajun Lu, Wei Gao, An'an Xu, Giang Quach, Kaijing Wang, Xiaogang Zhou |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Sleeve gastrectomy Endocrinology Diabetes and Metabolism medicine.medical_treatment 030209 endocrinology & metabolism Type 2 diabetes Anastomosis Gastroenterology Eating Random Allocation 03 medical and health sciences 0302 clinical medicine Gastrectomy Glucagon-Like Peptide 1 Ileum Weight loss Internal medicine Diabetes mellitus medicine Animals Insulin Obesity Glycemic Nutrition and Dietetics business.industry Anastomosis Surgical nutritional and metabolic diseases Fasting medicine.disease Lipids Rats Rats Zucker Surgery Disease Models Animal Jejunum Diabetes Mellitus Type 2 030211 gastroenterology & hepatology Ghrelin medicine.symptom business |
| Zdroj: | Obesity Surgery. 26:797-804 |
| ISSN: | 1708-0428 0960-8923 |
| DOI: | 10.1007/s11695-015-1811-7 |
| Popis: | Sleeve gastrectomy plus side-to-side jejunoileal anastomosis (JI-SG), a relatively new approach to bariatric surgeries, has shown promising results for treating obesity and metabolic comorbidities. This study investigated the feasibility and safety of JI-SG in weight loss and diabetes remission compared with sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB). Forty 10-week-old male Zucker diabetic fatty rats were randomly assigned to four groups: control, SG, JI-SG, and RYGB. Their body weights, food intake, and levels of gut hormones (ghrelin, insulin, and glucagon-like peptide-1 (GLP-1)) and lipids were measured. Rats in the SG, JI-SG, and RYGB groups demonstrated lower food intake and more weight loss 2 weeks postoperatively compared with control rats. Furthermore, rats in the JI-SG group achieved more weight loss (mean 242.7 ± 11.2 g) compared with those in the SG and RYGB groups (SG, 401.4 ± 15.1 g and RYGB, 298 ± 12 g, both P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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