Ophthalmologic manifestations of adult patients with cystic fibrosis
| Autor: | Menelaos Kanakis, Filia Diamantea, Maria Tzetis, Chrysanthi Koutsandrea, Dimitrios Papaconstantinou, Panagiotis Giannakouras, Ilias Georgalas |
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| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | European Journal of Ophthalmology. 32:976-983 |
| ISSN: | 1724-6016 1120-6721 |
| DOI: | 10.1177/11206721211008780 |
| Popis: | Introduction: Cystic fibrosis (CF) is the most common life-shortening recessive genetic disease in Caucasians, affecting primarily the lungs. The objective of our study was to investigate potential ophthalmologic involvement in adult patients with CF. Methods: Fifty adult patients with cystic fibrosis and 60 age- and sex-matched controls underwent complete ophthalmologic examination including tear-film Break-Up Time (BUT), Macular Thickness, and peripapillary Retinal Nerve Fiber Layer (pRNFL) thickness measurements using Spectral Domain-OCT. Results: CF patients had significantly lower nasal-inferior pRNFL thickness (median 82 IQR 67–102 vs 92.5 IQR 82–107, p = 0.005) and lower percentage of normal tear Break-Up Time (56.0% vs 96.7%, p = 0.001) than healthy controls. All CF patients with BUT Conclusions: Our study is, to the best of our knowledge, the largest ophthalmologic study of patients with cystic fibrosis. We found that CF patients had significantly decreased inferior-quadrant peripapillary retinal nerve fiber layer thickness and decreased tear-film break-up time compared to controls. We highlight the importance of careful regular ophthalmologic assessment and follow-up of these patients. |
| Databáze: | OpenAIRE |
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