Long term cardiovascular effects of oral antidiabetic agents in non-diabetic patients with insulin resistance: double blind, prospective, randomised study
Autor: | D A Stakos, H. Boudoulas, E. A. Sparks, Wooley Cf, D P Schuster, K Osei |
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Jazyk: | angličtina |
Rok vydání: | 2005 |
Předmět: |
Adult
Blood Glucose medicine.medical_specialty medicine.medical_treatment Heart Ventricles Administration Oral Blood Pressure Cardiovascular Medicine Placebo Insulin resistance Double-Blind Method Internal medicine Diabetes mellitus medicine Humans Hypoglycemic Agents Prospective Studies Pulse wave velocity Aorta Glucose tolerance test medicine.diagnostic_test business.industry Insulin Glucose Tolerance Test Middle Aged medicine.disease Lipids Metformin Endocrinology cardiovascular system Cardiology Insulin Resistance Cardiology and Cardiovascular Medicine business Lipid profile Blood Flow Velocity Glipizide medicine.drug |
Popis: | To study the long term cardiovascular effects of oral antidiabetic agents in non-diabetic patients with insulin resistance.181 African American subjects with insulin resistance and normal glucose tolerance test were randomised to receive glipizide 5 mg/day (n = 25), metformin 500 mg/day (n = 59), or placebo (n = 97) for 24 months. Insulin sensitivity, glucose tolerance, lipid profile, left ventricular mass (echocardiography), aortic distensibility (echocardiography, blood pressure), aortic pulse wave velocity (PWV, carotid to femoral artery, Doppler) were measured at baseline and at 12 and 24 months after randomisation.A significant increase in PWV was observed in both glipizide (mean (SEM) change at 24 months 2.8 (2.7) m/s, p = 0.012) and metformin (2.2 (0.7) m/s, p = 0.01) groups during the follow up period. In contrast, PWV remained unchanged in the placebo group. The increase in PWV in the treatment groups was significant compared with placebo (analysis of variance p0.05). Other cardiovascular or metabolic variables did not change significantly compared with placebo during follow up.The observed increase in PWV is consistent with a decrease in the elastic properties of the aorta. The use of oral antidiabetic agents for the prevention of cardiovascular complications in non-diabetic African Americans with insulin resistance needs to be critically evaluated. |
Databáze: | OpenAIRE |
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